Evidence map›Paper›PMID 30902814›Full record

ArticleThe Journal of biological chemistry2019

Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding.

Lisa M Parsons, Kim M Bouwman, Hugo Azurmendi, Robert P de Vries, John F Cipollo, Monique H Verheije

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 80 citations in OpenAlex.

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  19. Review
  20. The N1038S Substitution andFrontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lisa M ParsonsFrom the Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993.
Kim M Bouwmanthe Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands, and.
Hugo AzurmendiFrom the Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993.ORCID 0000-0003-3540-4585
Robert P de Vriesthe Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3512 JE Utrecht, The Netherlands.
John F CipolloFrom the Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, john.cipollo@fda.hhs.gov.
Monique H Verheijethe Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands, and.
Center for Biologics Evaluation and Research · USUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Avian coronaviruses, including infectious bronchitis virus (IBV), are important respiratory pathogens of poultry. The heavily glycosylated IBV spike protein is responsible for binding to host tissues. Glycosylation sites in the spike protein are highly conserved across viral genotypes, suggesting an important role for this modification in the virus life cycle. Here, we analyzed the

Indexed as

Molecular Docking SimulationAmino Acid SubstitutionAnimalsChickensGlycosylationHEK293 CellsHumansInfectious bronchitis virusMutation, MissenseProtein Structure, SecondarySpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusavian infectious bronchitis viruscell-surface receptorcomputational biologycoronavirusglycobiologyglycomicsglycoproteinglycosylationreceptor-bindingsialic acidspike proteinviral envelope

Identifiers

PMID30902814
PMCPMC6514631
OpenAlexW2922774445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.