Evidence map›Paper›PMID 30902692›Full record

Trial reportAmerican journal of ophthalmology2019

Visual Impairment in Fungal Versus Bacterial Corneal Ulcers 4 Years After Successful Antimicrobial Treatment.

Namperumalsamy V Prajna, Muthiah Srinivasan, Jeena Mascarenhas, Prajna Lalitha, Revathi Rajaraman, Scott M McClintic, Kieran S O'Brien, Kathryn J Ray, Nisha R Acharya, Thomas M Lietman and 1 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Infectious Keratitis Management: 10-Year Update.Journal of clinical medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. A Pilot Study to Evaluate Genipin inInternational journal of molecular sciences · 2023
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Namperumalsamy V PrajnaDepartment of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.
Muthiah SrinivasanDepartment of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.
Jeena MascarenhasDepartment of Cornea and External Diseases, Aravind Eye Care System, Madurai, India.
Prajna LalithaDepartment of Cornea and External Diseases, Aravind Eye Care System, Madurai, India; Department of Ocular Microbiology, Aravind Eye Care System, Madurai, India.
Revathi RajaramanDepartment of Cornea and External Diseases, Aravind Eye Care System, Coimbatore, India.
Scott M McClinticDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
Kieran S O'BrienFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
Kathryn J RayFrancis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
Nisha R AcharyaDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California, USA; Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
Thomas M LietmanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California, USA; Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Jeremy D KeenanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, California, USA; Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA. Electronic address: jeremy.keenan@ucsf.edu.
Aravind Eye Hospital · INUniversity of California, San Francisco · USSan Francisco Foundation · US

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 1985 to 2024
$16.8M
The Steroids for Cornea Ulcers TrialU10EY015114 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIETMAN, THOMAS M · 2005 to 2009
$2.4M
Optimal trachoma control after mass antibiotic distributionsK23EY019071 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEENAN, JEREMY DAVID · 2008 to 2012
$982k
NEI NIH HHS K23 EY019071NEI NIH HHS P30 EY002162NEI NIH HHS U10 EY015114
6 · The paper itself

Abstract

purposeTo compare longitudinal outcomes of visual acuity after fungal corneal ulcers with those of bacterial ulcers.

designProspective cohort study.

methodsThis study was conducted in a tertiary eye hospital in South India. The population consisted of 100 of 152 individuals whose fungal or bacterial keratitis had been diagnosed 4 years prior and had been enrolled in 1 of 2 concurrent randomized trials. Causative organisms of infectious keratitis were either bacterial or fungal. Presenting visual acuity consisted of best spectacle corrected visual acuity (BSCVA) and hard contact lens-corrected visual acuity (CLVA).

resultsFifty study participants with prior fungal keratitis and 50 with prior bacterial keratitis were enrolled. Four years after treatment for keratitis, participants' presenting vision in the better eye was worse than 20/60 for 12 individuals (24.0%) in the fungal group and 10 individuals (20.0%) in the bacterial group. Median BSCVA in the affected eye at the 4-year visit in the fungal group was similar to that in the bacterial group (Snellen equivalent, 20/32 for each), although vision worse than 20/400 was more common in the fungal ulcer group after spectacle correction (odds ratio [OR] 4.19; 95% confidence interval [CI], 1.11-15.8) and contact lens correction (OR, 5.74; 95% CI, 1.37-24.1).

conclusionsIn this South Indian population with a previous episode of fungal or bacterial keratitis, correctable bilateral visual impairment was common. Although long-term visual outcomes were, on average, similar between fungal and bacterial ulcers, fungal ulcers were more likely to produce severe visual impairment.

Indexed as

Visual AcuityAdultAnti-Bacterial AgentsAntifungal AgentsBacteriaCorneaEye Infections, BacterialEye Infections, FungalFemaleFollow-Up StudiesFungiHumansKeratoconusMaleMiddle AgedProspective StudiesAnti-Bacterial AgentsAntifungal Agents

Identifiers

PMID30902692
PMCPMC8075352
OpenAlexW2923570037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.