ArticleNeuroImage2019
On time delay estimation and sampling error in resting-state fMRI.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Combined Cognitive Training and Vortioxetine Mitigates Age-Related Declines in Functional Brain Network Integrity.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Trial
- Large-Vessel Venous Signal Confounds Apparent Amygdala Activation in BOLD fMRI.bioRxiv : the preprint server for biology · 2026Article
- Preserved intrinsic neural timescale organization with hierarchical variation in autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Feasibility of Precision Functional Mapping in Youth Multi-Echo fMRI Data.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporal Characterization of the Functional MRI Latency Structure with Respect to Neural Signaling and Brain Hierarchy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Motion impact score for detecting spurious brain-behavior associations.Nature communications · 2025Article
- Psilocybin's acute and persistent brain effects: a precision imaging drug trial.Scientific data · 2025Article
- The human brainstem's red nucleus was upgraded to support goal-directed action.Nature communications · 2025Article
- Symptom-based depression subtypes: brain dynamic specificity and its association with gene expression profiles.Translational psychiatry · 2025Article
- Neural mechanisms underlying synchronization of movement to musical cues in Parkinson disease and aging.Frontiers in neuroscience · 2025Article
- Cardiorespiratory Fitness and Sleep, but not Physical Activity, are Associated with Functional Connectivity in Older Adults.Sports medicine - open · 2024Article
- Complexity organization of resting-state functional-MRI networks.Human brain mapping · 2024Article
- Disuse-driven plasticity in the human thalamus and putamen.bioRxiv : the preprint server for biology · 2024Article
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2024Article
- Strategies for motion- and respiration-robust estimation of fMRI intrinsic neural timescales.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Temporal dysregulation of the somatomotor network in agitated depression.Brain communications · 2024Article
- Mechanisms of Action of TMS in the Treatment of Depression.Current topics in behavioral neurosciences · 2024Review
- Increasing hub disruption parallels dementia severity in autosomal dominant Alzheimer disease.bioRxiv : the preprint server for biology · 2023Article
- Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.Brain : a journal of neurology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Accumulating evidence indicates that resting-state functional magnetic resonance imaging (rsfMRI) signals correspond to propagating electrophysiological infra-slow activity (<0.1 Hz). Thus, pairwise correlations (zero-lag functional connectivity (FC)) and temporal delays among regional rsfMRI signals provide useful, complementary descriptions of spatiotemporal structure in infra-slow activity. However, the slow nature of fMRI signals implies that practical scan durations cannot provide sufficient independent temporal samples to stabilize either of these measures. Here, we examine factors affecting sampling variability in both time delay estimation (TDE) and FC. Although both TDE and FC accuracy are highly sensitive to data quantity, we use surrogate fMRI time series to study how the former is additionally related to the magnitude of a given pairwise correlation and, to a lesser extent, the temporal sampling rate. These contingencies are further explored in real data comprising 30-min rsfMRI scans, where sampling error (i.e., limited accuracy owing to insufficient data quantity) emerges as a significant but underappreciated challenge to FC and, even more so, to TDE. Exclusion of high-motion epochs exacerbates sampling error; thus, both sides of the bias-variance (or data quality-quantity) tradeoff associated with data exclusion should be considered when analyzing rsfMRI data. Finally, we present strategies for TDE in motion-corrupted data, for characterizing sampling error in TDE and FC, and for mitigating the influence of sampling error on lag-based analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.