Evidence map›Paper›PMID 30902489›Full record

ArticleUrologic oncology2019

A comparison of outcomes for standard and multiplex partial nephrectomy in a solitary kidney: The National Cancer Institute experience.

Joseph A Baiocco, Mark W Ball, Asha K Pappajohn, Kareem N Rayn, Gennady Bratslavsky, Shawna L Boyle, William M Linehan, Adam R Metwalli

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Urologic oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joseph A BaioccoUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Mark W BallDepartment of Urology, Upstate Medical University, Syracuse, New York. Electronic address: mark.ball@nih.gov.
Asha K PappajohnUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Kareem N RaynUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Gennady BratslavskyDepartment of Urology, Upstate Medical University, Syracuse, New York.
Shawna L BoyleUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
William M LinehanUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Adam R MetwalliUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
National Institutes of Health · USSUNY Upstate Medical University · US

Funding

Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase GeneZIABC011038 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LINEHAN, WILLIAM MARSTON · 2009 to 2025
$29.8M
Howard Hughes Medical InstituteIntramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

objectivesTo study the short and intermediate surgical, renal functional, and oncologic outcomes of multiplex partial nephrectomy (mPN) and standard partial nephrectomy (sPN) in the setting of a solitary kidney. PATIENTS AND

methodsReview of a prospectively maintained database of patients undergoing solitary kidney partial nephrectomy at our institution was performed. Patients were stratified into 2 cohorts: mPN-where 3 or more renal tumors were resected and sPN-where 1 or 2 tumors were resected. Perioperative, renal functional, and oncological outcomes were compared.

resultsNinety-three patients with a solitary kidney underwent a total of 121 surgical procedures; 43 (35.5%) were sPN and 78 (64.4%) were mPN. The total and major (Clavien Grade III and IV) complication rates between sPN and mPN were similar (57.1% vs. 70.1%, P = 0.2; 31.0% vs. 35.1%, P = 0.3). At 12 months post-op, the percentage of patients with eGFR > 45 was similar in each group (sPN 87.0%, mPN 73.7%; P = 0.2), and long-term hemodialysis rates were 4.7% and 6.4%, respectively. Completion nephrectomy was performed in 2.3% of sPN and 2.6% of mPN. At a median follow-up of 40.1 months, the metastasis rate was 8.6% in the sPN group and 4.1% in the mPN group (P = 0.4).

conclusionsPartial nephrectomy in the setting of a solitary kidney can effectively preserve renal function. The renal functional and oncologic outcomes were similar in sPN and mPN, with low hemodialysis rates and complication rates within the expected range of these operations. Three or more tumors in a solitary kidney should not be a contraindication for nephron sparing surgery.

Indexed as

AdultAgedFemaleHumansKidney NeoplasmsMaleMiddle AgedNational Cancer Institute (U.S.)NephrectomyRetrospective StudiesSolitary KidneyTreatment OutcomeUnited StatesMultifocal kidney tumorsMultiplex partial nephrectomyNephron sparing surgeryPartial nephrectomyRenal cell carcinomaSolitary kidney

Identifiers

PMID30902489
PMCPMC6535179
OpenAlexW2925023284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.