Evidence map›Paper›PMID 30902260›Full record

ReviewCurrent topics in developmental biology2019

Regulatory mechanisms of jaw bone and tooth development.

Yuan Yuan, Yang Chai

Abstract readReview
In one paragraph

Review in Current topics in developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  7. International journal of molecular sciences · 2025
    Article
  8. Article
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  12. International journal of molecular sciences · 2025
    Article
  13. An atlas of early human mandibular endochondral and osteogenic paracrine signaling regions of Meckel's cartilage.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. A Chemically Defined Culture for Tooth Reconstitution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuan YuanCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, United States. Electronic address: yuan164@usc.edu.
Yang ChaiCenter for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, United States. Electronic address: ychai@usc.edu.

Funding

Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE026914 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAI, YANG, CHEN, YONG · 2017 to 2019
$12.0M
TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESISR37DE012711 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG · 2009 to 2018
$4.3M
INTEGRATED RESEARCH OF FUNCTIONAL GENOMICS AND CRANIOFACIAL MORPHOGENESISU01DE024421 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG · 2014 to 2018
$1.6M
NIDCR NIH HHS R37 DE012711NIDCR NIH HHS U01 DE024421NIDCR NIH HHS U24 DE026914
6 · The paper itself

Abstract

Jaw bones and teeth originate from the first pharyngeal arch and develop in closely related ways. Reciprocal epithelial-mesenchymal interactions are required for the early patterning and morphogenesis of both tissues. Here we review the cellular contribution during the development of the jaw bones and teeth. We also highlight signaling networks as well as transcription factors mediating tissue-tissue interactions that are essential for jaw bone and tooth development. Finally, we discuss the potential for stem cell mediated regenerative therapies to mitigate disorders and injuries that affect these organs.

Indexed as

OdontogenesisAnimalsBody PatterningBranchial RegionHumansJawOsteogenesisRegenerative MedicineCranial neural crest cellsMandiblePatterningStem cells and tissue regenerationTooth

Identifiers

PMID30902260
PMCPMC6986348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.