ArticleBiomedical engineering online2019
Multiscale experimental study on the effects of different weight-bearing levels during moderate treadmill exercise on bone quality in growing female rats.
Article in Biomedical engineering online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Lifestyle clusters and bone mineral density in Chinese adults: a cross-sectional study with cluster analysis.Frontiers in endocrinology · 2026Article
- Effects of 24-week jumping exercise on bone mineral density and linear growth in children with short stature: a prospective controlled trial.BMC sports science, medicine & rehabilitation · 2025Article
- Association of CVAI with BMD, FRAX scores, and osteoporosis risk in Chinese elderly patients with hypertension.Scientific reports · 2025Article
- Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads.Journal of bone and mineral metabolism · 2024Article
- The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis.Aging and disease · 2023Review
- Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation.Biomedical engineering online · 2023Article
- Low-intensity pulsed ultrasound enhances the positive effects of high-intensity treadmill exercise on bone in rats.Journal of bone and mineral metabolism · 2023Article
- Association between Adiposity and Bone Mineral Density in Adults: Insights from a National Survey Analysis.Nutrients · 2023Article
- Biomechanical evaluation of different strain judging criteria on the prediction precision of cortical bone fracture simulation under compression.Frontiers in bioengineering and biotechnology · 2023Article
- Saturation Effect of Body Mass Index on Bone Mineral Density in Adolescents of Different Ages: A Population-Based Study.Frontiers in endocrinology · 2022Article
- Investigation on the Differences in the Failure Processes of the Cortical Bone under Different Loading Conditions.Applied bionics and biomechanics · 2022Article
- Obesity and Bone: A Complex Relationship.International journal of molecular sciences · 2021Review
- Exercise improves bone formation by upregulating the Wnt3a/β-catenin signalling pathway in type 2 diabetic mice.Diabetology & metabolic syndrome · 2021Article
- Does Physical Exercise Always Improve Bone Quality in Rats?Life (Basel, Switzerland) · 2020Review
- Effects of treadmill with different intensities on bone quality and muscle properties in adult rats.Biomedical engineering online · 2019Article
- The effect of tail suspension and treadmill exercise on LRP6 expression, bone mass and biomechanical properties of hindlimb bones in SD rats.American journal of translational research · 2019Article
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6 authors.
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Abstract
backgroundBone tissue displays a hierarchical organization. Mechanical environments influence bone mass and structure. This study aimed to explore the effects of different mechanical stimuli on growing bone properties at macro-micro-nano scales.
methodsSixty five-week-old female Wistar rats were treadmill exercised at moderate intensity with the speed of 12 m/min, and then randomly divided into five groups according to weight-bearing level. After 8 weeks of experiment, femurs were harvested to perform multiscale tests.
resultsBone formation was significantly increased by weight-bearing exercise, whereas bone resorption was not significantly inhibited. Trabecular and cortical bone mineral densities showed no significant increase by weight-bearing exercise. The microstructure of trabecular bone was significantly improved by 12% weight-bearing exercise. However, similar positive effects were not observed with further increase in weight-bearing levels. The nanomechanical properties of trabecular bone were not significantly changed by weight-bearing exercise. The macrostrength of whole femur and the nanomechanical properties of cortical bone significantly decreased in the 19% and 26% weight-bearing exercise groups.
conclusionWhen rats ran on the treadmill at moderate intensity during growth period, additional 12% weight-bearing level could significantly increase bone formation, improve microstructure of trabecular bone, as well as maintain the structure and mechanical properties of cortical bone. Excessive weight-bearing level caused no positive effects on the trabecular bone microstructure and properties of cortical bone at all scales. In addition, increased weight-bearing level exerted no significant influence on trabecular and cortical bone mineral densities.
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