Evidence map›Paper›PMID 30902101›Full record

ArticleOrphanet journal of rare diseases2019

Health services use among children diagnosed with medium-chain acyl-CoA dehydrogenase deficiency through newborn screening: a cohort study in Ontario, Canada.

Maria D Karaceper, Sara D Khangura, Kumanan Wilson, Doug Coyle, Marni Brownell, Christine Davies, Linda Dodds, Annette Feigenbaum, Deshayne B Fell, Scott D Grosse and 20 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 15 institutions in 2 countries.

Maria D KaraceperSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada.
Sara D KhanguraSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada.
Kumanan WilsonSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada.
Doug CoyleSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada.
Marni BrownellManitoba Centre for Health Policy, Department of Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Christine DaviesNewborn Screening Ontario, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Linda DoddsDepartments of Obstetrics & Gynecology and Pediatrics, Dalhousie University, Halifax, Canada.
Annette FeigenbaumDepartment of Pediatrics, Division of Clinical & Metabolic Genetics, The Hospital for Sick Children and University of Toronto, Toronto, Canada.
Deshayne B FellSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada.
Scott D GrosseCenters for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, USA.
Astrid GuttmannChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada.
Steven HawkenSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada.
Robin Z HayeemsChild Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada.
Jonathan B KronickDepartment of Pediatrics, Division of Clinical & Metabolic Genetics, The Hospital for Sick Children and University of Toronto, Toronto, Canada.
Anne-Marie LabergeMedical Genetics, CHU Sainte-Justine and Department of Pediatrics, Université de Montréal, Montreal, Canada.
Julian LittleSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada.
Aizeddin MhanniDepartment of Paediatrics and Child Health, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
John J MitchellMontreal Children's Hospital, McGill University, Montreal, Canada.
Meranda NakhlaMontreal Children's Hospital, McGill University, Montreal, Canada.
Murray PotterDepartment of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Chitra PrasadLondon Health Sciences Centre, Western University, London, Canada.
Cheryl Rockman-GreenbergDepartment of Paediatrics and Child Health, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Rebecca SparkesDepartment of Paediatrics, Section of Clinical Genetics, Alberta Children's Hospital, Calgary, Canada.
Sylvia StocklerChildren's & Women's Health Centre of British Columbia, Vancouver, Canada.
Keiko UedaChildren's & Women's Health Centre of British Columbia, Vancouver, Canada.
Hilary VallanceBiochemical Genetics Laboratory, Children's & Women's Health Centre of British Columbia, Vancouver, Canada.
Brenda J WilsonDivision of Community Health and Humanities, Memorial University of Newfoundland, St. John's, Canada.
Pranesh ChakrabortyDepartment of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Beth K PotterSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Cr, Ottawa, ON, K1G 5Z3, Canada. bpotter@uottawa.ca.ORCID 0000-0001-8374-6542
Canadian Inherited Metabolic Diseases Research Network (CIMDRN)
University of Ottawa · CAUniversity of Toronto · CAChildren's & Women's Health Centre of British Columbia · CAMontreal Children's Hospital · CAUniversity of Manitoba · CAAlberta Children's Hospital · CACenters for Disease Control and Prevention · USCentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital of Eastern Ontario · CADalhousie University · CAManitoba Health · CAMcMaster University Medical Centre · CAMemorial University of Newfoundland · CAUniversity of British Columbia · CAWestern University · CA

Funding

CIHR TR3-119195
6 · The paper itself

Abstract

backgroundWe describe early health services utilization for children diagnosed with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency through newborn screening in Ontario, Canada, relative to a screen negative comparison cohort.

methodsEligible children were identified via newborn screening between April 1, 2006 and March 31, 2010. Age-stratified rates of physician encounters, emergency department (ED) visits and inpatient hospitalizations to March 31, 2012 were compared using incidence rate ratios (IRR) and incidence rate differences (IRD). We used negative binomial regression to adjust IRRs for sex, gestational age, birth weight, socioeconomic status and rural/urban residence.

resultsThroughout the first few years of life, children with MCAD deficiency (n = 40) experienced statistically significantly higher rates of physician encounters, ED visits, and hospital stays compared with the screen negative cohort. The highest rates of ED visits and hospitalizations in the MCAD deficiency cohort occurred from 6 months to 2 years of age (ED use: 2.1-2.5 visits per child per year; hospitalization: 0.5-0.6 visits per child per year), after which rates gradually declined.

conclusionsThis study confirms that young children with MCAD deficiency use health services more frequently than the general population throughout the first few years of life. Rates of service use in this population gradually diminish after 24 months of age.

Indexed as

Acyl-CoA DehydrogenaseBirth WeightChild, PreschoolCohort StudiesEmergency Service, HospitalFemaleGestational AgeHealth Services MisuseHospitalizationHumansInfantInfant, NewbornLipid Metabolism, Inborn ErrorsMaleNeonatal ScreeningOntarioAcyl-CoA DehydrogenaseHealth service utilizationInherited metabolic diseasesMedium-chain acyl-CoA dehydrogenase deficiencyNewborn screening

Identifiers

PMID30902101
PMCPMC6431026
OpenAlexW2940064258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.