Evidence map›Paper›PMID 30902043›Full record

ArticleBMC cardiovascular disorders2019

Impaired myocardial perfusion is associated with increasing end-systolic- and end-diastolic volumes in patients with non-ischemic systolic heart failure: a cross-sectional study using Rubidium-82 PET/CT.

Christina Byrne, Philip Hasbak, Andreas Kjaer, Jens Jakob Thune, Lars Køber

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00541268 (A DANish Randomized, Controlled, Multicenter Study to Assess the Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality. The DANISH Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00541268 nacompletednot on this map

A DANish Randomized, Controlled, Multicenter Study to Assess the Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality. The DANISH Study

TypeinterventionalSponsorDanish Study GroupRan2008 to 2016Enrolled1,116ConditionsHeart Failure, Dilated Cardiomyopathy, Reduced LVEFArmsICD, Optimal medical treatment
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christina ByrneDepartment of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, 9441, Blegdamsvej 9, 2100-Cph, Copenhagen, Denmark. christina.byrne.faurholt.aagaard@regionh.dk.ORCID 0000-0003-2705-3367
Philip HasbakDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Andreas KjaerDepartment of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Jens Jakob ThuneDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Lars KøberDepartment of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, 9441, Blegdamsvej 9, 2100-Cph, Copenhagen, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial flow reserve (MFR, stress/rest myocardial blood flow) is a strong marker of myocardial vasomotor function. MFR is a predictor of adverse cardiac events in patients with non-ischemic systolic heart failure and previous studies using different methods have found association between myocardial blood flow and left ventricular dilatation. The aim of this study was to investigate whether there is an association between increasing end-systolic- and end-diastolic volumes (ESV and EDV) and MFR in these patients measured with Rubidium-82 positron emission tomography computed tomography (

methodsWe scanned 151 patients with non-ischemic heart failure with initial left ventricular ejection fraction ≤35% with

resultsMedian age was 62 years (55-69 years) and 31% were women. Mean MFR was 2.38 (2.24-2.52). MFR decreased significantly with both increasing ESVI (estimate - 3.7%/10 ml/m

conclusionsImpaired MFR assessed by

trial registrationSub study of the randomized clinical trial: A DANish randomized, controlled, multicenter study to assess the efficacy of Implantable cardioverter defibrillator in patients with non-ischemic Systolic Heart failure on mortality (DANISH), ClinicalTrials.gov Identifier: NCT00541268 .

Indexed as

Coronary CirculationPositron Emission Tomography Computed TomographyStroke VolumeVentricular Function, LeftAgedCross-Sectional StudiesDenmarkFemaleHeart Failure, SystolicHumansMaleMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsRadiopharmaceuticalsRandomized Controlled Trials as TopicRadiopharmaceuticalsRubidium RadioisotopesEnd diastolic volumeEnd systolic volumeMyocardial flow reserveMyocardial perfusion imagingNon-ischemic systolic heart failure

Identifiers

PMID30902043
PMCPMC6431039
OpenAlexW2942049055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.