Evidence map›Paper›PMID 30902024›Full record

ArticleXenobiotica; the fate of foreign compounds in biological systems2020

Impact of cytochrome P450 variation on meperidine

Jessica L Murray, Susan L Mercer, Klarissa D Jackson

Open access · greenAbstract read
In one paragraph

Article in Xenobiotica; the fate of foreign compounds in biological systems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol.Drug metabolism and disposition: the biological fate of chemicals · 2021
    Article
  4. Pethidine, Maybe a Rearrangement in the Pharmaceutical Group Is Needed!Iranian journal of pharmaceutical research : IJPR
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jessica L MurrayDepartment of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, TN, USA.
Susan L MercerDepartment of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, TN, USA.
Klarissa D JacksonDepartment of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-9388-9800
Lipscomb University · US

Funding

Role of Cytochrome P450 3A5 in the Metabolism and Hepatotoxicity of LapatinibK01CA190711 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JACKSON, KLARISSA D · 2014 to 2018
$659k
NCI NIH HHS K01 CA190711
6 · The paper itself

Abstract

1. Meperidine is an opioid analgesic that undergoes

Indexed as

Cholinesterase InhibitorsCytochrome P-450 CYP2C19Cytochrome P-450 Enzyme SystemDemethylationHumansMeperidineMephenytoinCholinesterase InhibitorsCytochrome P-450 CYP2C19Cytochrome P-450 Enzyme SystemMeperidineMephenytoinnormeperidineCytochrome P450genetic polymorphismmeperidineneurotoxic metabolitereaction phenotyping

Identifiers

PMID30902024
PMCPMC7755165
OpenAlexW2940855354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.