Evidence map›Paper›PMID 30901934›Full record

ArticleMolecules (Basel, Switzerland)2019

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus.

Ewelina Krol, Ilona Wandzik, Gabriela Brzuska, Luděk Eyer, Daniel Růžek, Boguslaw Szewczyk

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ewelina KrolDepartment of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland. ewelina@biotech.ug.gda.pl.ORCID 0000-0001-8573-4254
Ilona WandzikDepartment of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego 4, 44-100 Gliwice, Poland. Ilona.Wandzik@polsl.pl.ORCID 0000-0002-6592-4875
Gabriela BrzuskaDepartment of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland. gabriela.brzuska@phdstud.ug.edu.pl.
Luděk EyerDepartment of Virology, Veterinary Research Institute, Hudcova 70, CZ-62100 Brno, Czech Republic. eyer@vri.cz.
Daniel RůžekDepartment of Virology, Veterinary Research Institute, Hudcova 70, CZ-62100 Brno, Czech Republic. ruzekd@paru.cas.cz.ORCID 0000-0003-4655-2380
Boguslaw SzewczykDepartment of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland. szewczyk@biotech.ug.gda.pl.

Funding

Narodowe Centrum Nauki UMO-2015/19/D/NZ6/01717
6 · The paper itself

Abstract

Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system. Although effective vaccines are available on the market, they are recommended only in endemic areas. Despite many attempts, there are still no specific antiviral therapies for TBEV treatment. Previously, we synthesized a series of uridine derivatives of 2-deoxy sugars and proved that some compounds show antiviral activity against viruses from the Flaviviridae and Orthomyxoviridae families targeting the late steps of the

Indexed as

Antiviral AgentsCell Line, TumorCells, CulturedDeoxy SugarsDose-Response Relationship, DrugEncephalitis Viruses, Tick-BorneHumansMicrobial Sensitivity TestsMolecular StructureProtein BiosynthesisUridineViral Plaque AssayAntiviral AgentsDeoxy SugarsUridine2-deoxy sugarsantiviralsglycosylation inhibitiontick-borne encephalitisuridine

Identifiers

PMID30901934
PMCPMC6471225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.