Evidence map›Paper›PMID 30901888›Full record

ArticleMaterials (Basel, Switzerland)2019

Cationic Albumin Encapsulated DNA Origami for Enhanced Cellular Transfection and Stability.

Xuemei Xu, Shiqi Fang, Yuan Zhuang, Shanshan Wu, Qingling Pan, Longjie Li, Xiaohui Wang, Xueqing Sun, Bifeng Liu, Yuzhou Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Hybrid Nanoassemblies from Viruses and DNA Nanostructures.Nanomaterials (Basel, Switzerland) · 2021
    Review
  8. DNA Transformations for Diagnosis and Therapy.Advanced functional materials · 2021
    Review
  9. Review
  10. Effect of DNA Origami Nanostructures on hIAPP Aggregation.Nanomaterials (Basel, Switzerland) · 2020
    Article
  11. Challenges and Perspectives of DNA Nanostructures in Biomedicine.Angewandte Chemie (International ed. in English) · 2020
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Xuemei XuBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. xuxuemei@hust.edu.cn.
Shiqi FangBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. fangshiqi@hust.edu.cn.
Yuan ZhuangBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. zhuangyuan@hust.edu.cn.
Shanshan WuBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. wushanshan@hust.edu.cn.
Qingling PanBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. panqingling@hust.edu.cn.
Longjie LiBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. lilongjie18@hust.edu.cn.
Xiaohui WangBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. m201670275@hust.edu.cn.
Xueqing SunBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. sunxueqing@hust.edu.cn.
Bifeng LiuBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. bfliu@hust.edu.cn.
Yuzhou WuBritton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics, Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. wuyuzhou@hust.edu.cn.
Huazhong University of Science and Technology · CNWuhan National Laboratory for Optoelectronics · CN

Funding

Deutsche Forschungsgemeinschaft SFB1279National Natural Science Foundation of China 51703073the Fundamental Research Funds for the Central Universities of China 2017KFYXJJ167
6 · The paper itself

Abstract

DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under physiological conditions, and endonuclease degradation. Herein, we demonstrate an effective approach to facilitate fast transfection of DNA nanostructures and enhance their stability by encapsulating DNA origami with a biocompatible cationic protein (cHSA) via electrostatic interaction. The coated DNA origami is found to be stable under physiological conditions. Moreover, the cHSA coating could significantly improve the cellular transfection efficiency of DNA origami, which is essential for biological applications.

Indexed as

cationic albumincellular uptakeDNA origamistability

Identifiers

PMID30901888
PMCPMC6470866
OpenAlexW2922638561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.