ArticleNeuroImage. Clinical2019
More than myelin: Probing white matter differences in prematurity with quantitative T1 and diffusion MRI.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Quantitative T1 Mapping Indicates Elevated White Matter Myelin in Children With RASopathies.Biological psychiatry · 2025Article
- Listening to mom in the neonatal intensive care unit: a randomized trial of increased maternal speech exposure on white matter connectivity in infants born preterm.Frontiers in human neuroscience · 2025Article
- Fast and reliable quantitative measures of white matter development with magnetic resonance fingerprinting.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neonatal inflammation and near-term white matter microstructure in infants born very preterm.Neuroimage. Reports · 2024Article
- Increased white matter fibre dispersion and lower IQ scores in adults born preterm.Human brain mapping · 2024Article
- A comprehensive protocol for quantitative magnetic resonance imaging of the brain at 3 Tesla.PloS one · 2024Article
- Quantitative MRI Characterization of the Extremely Preterm Brain at Adolescence: Atypical versus Neurotypical Developmental Pathways.Radiology · 2022Article
- Brain White Matter Development Over the First 13 Years in Very Preterm and Typically Developing Children Based on theNeurology · 2022Article
- Neurobiological underpinnings of rapid white matter plasticity during intensive reading instruction.NeuroImage · 2021Article
- Speech rate association with cerebellar white-matter diffusivity in adults with persistent developmental stuttering.Brain structure & function · 2021Article
- A Comparison of Quantitative R1 and Cortical Thickness in Identifying Age, Lifespan Dynamics, and Disease States of the Human Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Reduced apparent fiber density in the white matter of premature-born adults.Scientific reports · 2020Article
- White matter microstructure and cognitive outcomes in relation to neonatal inflammation in 6-year-old children born preterm.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveWe combined diffusion MRI (dMRI) with quantitative T1 (qT1) relaxometry in a sample of school-aged children born preterm and full term to determine whether reduced fractional anisotropy (FA) within the corpus callosum of the preterm group could be explained by a reduction in myelin content, as indexed by R1 (1/T1) from qT1 scans.
methods8-year-old children born preterm (n = 29; GA 22-32 weeks) and full term (n = 24) underwent dMRI and qT1 scans. Four subdivisions of the corpus callosum were segmented in individual native space according to cortical projection zones (occipital, temporal, motor and anterior-frontal). Fractional anisotropy (FA) and R1 were quantified along the tract trajectory of each subdivision and compared across two birth groups.
resultsCompared to controls, preterm children demonstrated significantly decreased FA in 3 of 4 analyzed corpus callosum subdivisions (temporal, motor, and anterior frontal segments) and decreased R1 in only 2 of 4 corpus callosum subdivisions (temporal and motor segments). FA and RD were significantly associated with R1 within temporal but not anterior frontal subdivisions of the corpus callosum in the term group; RD correlated with R1 in the anterior subdivision in the preterm group only.
conclusionsMyelin content, as indexed by R1, drives some but not all of the differences in white matter between preterm and term born children. Other factors, such as axonal diameter and directional coherence, likely contributed to FA differences in the anterior frontal segment of the corpus callosum that were not well explained by R1.
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