ArticlePloS one2019
Morphological characteristics and microstructure of kidney stones using synchrotron radiation μCT reveal the mechanism of crystal growth and aggregation in mixed stones.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Separate core-shell analysis of urinary stones may influence specific metaphylaxis.World journal of urology · 2026Article
- Kidney Stones as Minerals: How Methods from Geology Could Inform Urolithiasis Treatment.Journal of clinical medicine · 2025Review
- Impact of Obesity on Hospitalization Burden of Urolithiasis in Spain Between 1997 and 2021.Journal of clinical medicine · 2025Article
- The key role of major and trace elements in the formation of five common urinary stones.BMC urology · 2024Article
- Kidney stone growth through the lens of Raman mapping.Scientific reports · 2024Article
- Sample preparation and analysis protocols for the elucidation of structure and chemical distribution in kidney stones.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2024Article
- Theranostic roles of machine learning in clinical management of kidney stone disease.Computational and structural biotechnology journal · 2023Review
- Multidisciplinary investigation of an ancient renal stone in a mummy from Popoli, central Italy.Pathologica · 2022Article
- Bioinformatics analysis of pathways of renal infiltrating macrophages in different renal disease models.Translational andrology and urology · 2021Article
- Automated radiomic analysis of CT images to predict likelihood of spontaneous passage of symptomatic renal stones.Emergency radiology · 2021Article
- The surgeon's role on chemical investigations of the composition of urinary stones.Urolithiasis · 2020Article
- Microstructural diversity of gallstones revealed by spectral microanalyses and their association with hepatic parameters.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
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5 authors.
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Abstract
Understanding the mechanisms of kidney stone formation, development patterns and associated pathological features are gaining importance due to an increase in the prevalence of the disease and diversity in the presentation of the stone composition. Based on the microstructural characteristics of kidney stones, it may be possible to explain the differences in the pathogenesis of pure and mixed types of stones. In this study, the microstructure and distribution of mineral components of kidney stones of different mineralogy (pure and mixed types) were analyzed. The intact stones removed from patients were investigated using synchrotron radiation X-ray computed microtomography (SR-μCT) and the tomography slice images were reconstructed representing the density and structure distribution at various elevation planes. Infrared (IR) spectroscopes, X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to confirm the bulk mineral composition in the thin section stones. Observations revealed differences in the micro-morphology of the kidney stones with similar composition in the internal 3-D structure. Calcium oxalate monohydrate stones showed well-organised layering patterns, while uric acid stones showed lower absorption signals with homogenous inner structure. Distinct mineral phases in the mixed types were identified based on the differential absorption rates. The 3-D quantitative analysis of internal porosity and spatial variation between nine different types of stones were compared. The diversity among the microstructure of similar and different types of stones shows that the stone formation is complex and may be governed by both physiological and micro-environmental factors. These factors may predispose a few towards crystal aggregation and stone growth, while, in others the crystals may not establish stable attachment and/or growth.
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