Evidence map›Paper›PMID 30901029›Full record

ReviewEndocrine reviews2019

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.

Julian M Yabut, Justin D Crane, Alexander E Green, Damien J Keating, Waliul I Khan, Gregory R Steinberg

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06138509 (Role of Peripheral Serotonin in Oculocutaneous Albinism), which is not on this map. Cited by 220 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 3 pooled it
20.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06138509 recruitingnot on this mapstarted 2024, after this paper: background citation

Role of Peripheral Serotonin in Oculocutaneous Albinism

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2024 to 2026Enrolled160ConditionsOculocutaneous AlbinismArmsDosage of serotonin and metabolites, Blood parameters
3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 3 syntheses or guidelines pooled it, 391 citations in OpenAlex.

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160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Julian M YabutDivision of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Justin D CraneDepartment of Biology, Northeastern University, Boston, Massachusetts.
Alexander E GreenDivision of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Damien J KeatingCollege of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Waliul I KhanCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Gregory R SteinbergDivision of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
McMaster University · CAFlinders University · AUNortheastern University · USPopulation Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonin is a phylogenetically ancient biogenic amine that has played an integral role in maintaining energy homeostasis for billions of years. In mammals, serotonin produced within the central nervous system regulates behavior, suppresses appetite, and promotes energy expenditure by increasing sympathetic drive to brown adipose tissue. In addition to these central circuits, emerging evidence also suggests an important role for peripheral serotonin as a factor that enhances nutrient absorption and storage. Specifically, glucose and fatty acids stimulate the release of serotonin from the duodenum, promoting gut peristalsis and nutrient absorption. Serotonin also enters the bloodstream and interacts with multiple organs, priming the body for energy storage by promoting insulin secretion and de novo lipogenesis in the liver and white adipose tissue, while reducing lipolysis and the metabolic activity of brown and beige adipose tissue. Collectively, peripheral serotonin acts as an endocrine factor to promote the efficient storage of energy by upregulating lipid anabolism. Pharmacological inhibition of serotonin synthesis or signaling in key metabolic tissues are potential drug targets for obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD).

Indexed as

Adipose Tissue, BrownAdipose Tissue, WhiteAnimalsEnergy MetabolismHumansLipid MetabolismSerotoninSignal TransductionSerotonin

Identifiers

PMID30901029
PMCPMC6624793
OpenAlexW2937633928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.