Evidence map›Paper›PMID 30900874›Full record

ArticleBiochemistry2019

Non-nucleoside Reverse Transcriptase Inhibitors Inhibit Reverse Transcriptase through a Mutually Exclusive Interaction with Divalent Cation-dNTP Complexes.

Jeffrey J DeStefano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jeffrey J DeStefanoDepartment of Cell Biology and Molecular Genetics and the Maryland Pathogen Research Institute , University of Maryland , College Park , Maryland 20742 , United States.ORCID 0000-0002-8710-7622
University of Maryland, College Park · US

Funding

Biochemistry of HIV reverse transcriptase fidelity and inhibitor interactionsR01GM116645 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DESTEFANO, JEFFREY J · 2016 to 2018
$924k
Biochemistry of HIV reverse transcriptase fidelity and inhibitor interactionsR01AI150480 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI DESTEFANO, JEFFREY J · 2019 to 2019
$294k
NIAID NIH HHS R01 AI150480NIGMS NIH HHS R01 GM116645
6 · The paper itself

Abstract

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are considered noncompetitive inhibitors that structurally alter reverse transcriptase (RT) and dramatically decrease catalysis. In this report, biochemical analysis with various divalent cations was used to demonstrate that NNRTIs and divalent cation-dNTP complexes are mutually exclusive, inhibiting each other's binding to RT/primer/template (RT-P/T) complexes. The binding of catalytically competent divalent cation-dNTP complexes to RT-P/T was measured with Mg

Indexed as

AlkynesAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBase SequenceBenzoxazinesBinding, CompetitiveCations, DivalentCyclopropanesHIV-1HIV InfectionsHIV Reverse TranscriptaseHumansNucleotidesProtein BindingReverse Transcriptase InhibitorsRilpivirineAlkynesAnti-HIV AgentsBenzoxazinesCations, DivalentCyclopropanesefavirenzHIV Reverse TranscriptaseNucleotidesReverse Transcriptase InhibitorsRilpivirine

Identifiers

PMID30900874
PMCPMC6629025
OpenAlexW2925252240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.