ArticleMolecular pain
Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache.
Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Part Of the Process, or Adverse Event? Considering the Benefits and Potential Risks of Mindfulness-based Interventions for Migraine.Current pain and headache reports · 2025Review
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- Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine.The journal of headache and pain · 2023Article
- Emerging Materials, Wearables, and Diagnostic Advancements in Therapeutic Treatment of Brain Diseases.Biosensors · 2022Review
- Functional connectivity and structural changes of thalamic subregions in episodic migraine.The journal of headache and pain · 2022Article
- Review
- Involvement of the cerebellum in migraine.Frontiers in systems neuroscience · 2022Review
- Applications in Awake Animal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
- CGRP Administration Into the Cerebellum Evokes Light Aversion, Tactile Hypersensitivity, and Nociceptive Squint in Mice.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis.Frontiers in neurology · 2022Review
- Brain fMRI during orientation selective epidural spinal cord stimulation.Scientific reports · 2021Article
- Role of the Anterior Cingulate Cortex in Translational Pain Research.Neuroscience bulletin · 2021Review
- Detecting Abnormal Neuronal Activity in a Chronic Migraine Model by Egr1-EGFP Transgenic Mice.Frontiers in neuroscience · 2021Article
- Altered Posterior Cerebellar Lobule Connectivity With Perigenual Anterior Cingulate Cortex in Women With Primary Dysmenorrhea.Frontiers in neurology · 2021Article
- Effect of Electroacupuncture on Hyperalgesia and Vasoactive Neurotransmitters in a Rat Model of Conscious Recurrent Migraine.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study.Molecular painArticle
- Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice.Molecular painArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explored the atypical functional connectivity between the anterior cingulate cortex and other brain areas in rats subjected to repeated meningeal nociception. The rat model was established by infusing an inflammatory soup through supradural catheters in conscious rats. Rats were subdivided according to the frequency of the inflammatory soup infusions. Functional connectivity analysis seeded on the anterior cingulate cortex was performed on rats 21 days after inflammatory soup infusion. Glyceryl trinitrate was injected following baseline scanning in the low-frequency inflammatory soup group and magnetic resonance imaging data were acquired 1 h after the injection. The rats exhibited nociceptive behavior after high-frequency inflammatory soup infusion. The anterior cingulate cortex showed increased functional connectivity with the cerebellum in the inflammatory soup groups. The medulla showed increased functional connectivity with the anterior cingulate cortex in the ictal period in the low-frequency inflammatory soup rats. Several areas showed increased functional connectivity with the anterior cingulate cortex in the high-frequency inflammatory soup group, including the pontine tegmentum, midbrain, thalamus, corpus callosum, hippocampus, and retrosplenial, visual, sensory, and motor cortices. This study indicated that the medulla participates in the early stage of a migraine attack and may be associated with the initiation of migraine. Sensitization of the trigeminal nociceptive pathway might contribute to the cutaneous allodynia seen in chronic migraine. Brain areas important for memory function may be related to the chronification of migraine. Electrophysiological studies should examine those migraine-related areas and provide new targets for migraine treatment and prevention.
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