Evidence map›Paper›PMID 30900424›Full record

ArticleYonsei medical journal2019

A Feasibility Study for Diagnosis of Latent Tuberculosis Infection Using an IGRA Point-of-Care Platform in South Korea.

Yun Gyoung Hur, Ji Young Hong, Dong Hwan Choi, Ahreum Kim, So Yeong Park, Minsuk Kwon, Kyungjoon Kang, Jeong Min Lee, Hazel M Dockrell, Yoonsuk Lee and 2 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Yonsei medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Diagnostic Performance of New Commercial Interferon-Gamma Release Assays for Mycobacterium tuberculosis Infection: An Updated Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Evaluation of a lateral-flow nanoparticle fluorescence assay for TB infection diagnosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yun Gyoung HurInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea. hur1225@gmail.com.ORCID 0000-0003-3986-4394
Ji Young HongDepartment of Pulmonary and Critical Care Medicine, Hallym University Medical Center, Chuncheon, Korea.ORCID 0000-0002-3132-7706
Dong Hwan ChoiBoditech Med Inc., Chuncheon, Korea.ORCID 0000-0001-9404-0107
Ahreum KimInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0001-5938-4270
So Yeong ParkDepartment of Pulmonary and Critical Care Medicine, Hallym University Medical Center, Chuncheon, Korea.ORCID 0000-0002-2676-6886
Minsuk KwonBoditech Med Inc., Chuncheon, Korea.ORCID 0000-0003-0565-994X
Kyungjoon KangBoditech Med Inc., Chuncheon, Korea.ORCID 0000-0002-1207-9583
Jeong Min LeeBoditech Med Inc., Chuncheon, Korea.ORCID 0000-0002-5834-2930
Hazel M DockrellDepartment of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-1869-9107
Yoonsuk LeeBoditech Med Inc., Chuncheon, Korea.ORCID 0000-0003-1767-7766
Hoodon JooBoditech Med Inc., Chuncheon, Korea.ORCID 0000-0001-9688-1583
Sang Nae ChoInstitute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0003-3008-3727
Boditech Med (South Korea) · KRYonsei University · KRHallym University · KRLondon School of Hygiene & Tropical Medicine · GB

Funding

Boditech Med Inc.YUCM
6 · The paper itself

Abstract

purposeThis study aimed to evaluate ichroma™ IGRA-TB, a novel point-of-care platform for assaying IFN-γ release, and to compare it with QuantiFERON-TB Gold In-Tube (QFT-GIT) for identifying MATERIALS AND

methodsWe recruited 60 healthy subjects, and blood samples were obtained in QFT-GIT blood collection tubes. The blood collection tubes were incubated at 37°C, and culture supernatant was harvested after 18-24 hours. IFN-γ responses were assessed by the ichroma™ IGRA-TB cartridge and the QFT-GIT IFN-γ enzyme-linked immunosorbent assay. Three active TB patients were recruited as a positive control for

resultsThe area under the receiver operating characteristic curve of the ichroma™ IGRA-TB test for differentiating between infected and non-infected individuals was 0.9706 (

conclusionThe diagnostic accuracy demonstrated in this study indicates that the ichroma™ IGRA-TB test could be used as a rapid diagnostic method for detecting latent TB infection. It may be particularly beneficial in resource-limited places that require cost-effective laboratory diagnostics.

Indexed as

Point-of-Care SystemsAdultArea Under CurveCase-Control StudiesEnzyme-Linked Immunosorbent AssayFeasibility StudiesFemaleHumansInterferon-gammaInterferon-gamma Release TestsLatent TuberculosisMaleMycobacterium tuberculosisReagent Kits, DiagnosticRepublic of KoreaROC CurveInterferon-gammaReagent Kits, Diagnosticichroma™ IGRA-TBIFN-γlatent TB infectionpoint-of-care platformQuantiFERON-TB Gold In-Tube testtuberculosis

Identifiers

PMID30900424
PMCPMC6433574
OpenAlexW2925283195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.