ArticleThe Plant journal : for cell and molecular biology2019
Structural diversification during glucosinolate breakdown: mechanisms of thiocyanate, epithionitrile and simple nitrile formation.
Article in The Plant journal : for cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- From Glucosinolate Content to Isothiocyanate Yield: RethinkingNutrients · 2026Review
- Biochemical characterization of twoFrontiers in plant science · 2026Article
- Impacts of Sulfur on Glucosinolate Metabolism: FromPlants (Basel, Switzerland) · 2025Review
- Application of Microorganisms for the Valorization of Side-Products of Rapeseed De-Oiling.Biomolecules · 2025Review
- The Effect of the Glucosinolate Sinigrin on Alterations in Molecular Biomarkers of the Myocardium in Swiss Mice.Foods (Basel, Switzerland) · 2025Article
- Nitrilases NIT1/2/3 Positively Regulate Resistance toInternational journal of molecular sciences · 2024Article
- Adaptive modifications in plant sulfur metabolism over evolutionary time.Journal of experimental botany · 2024Review
- Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane.Biomedicines · 2024Review
- The Antimicrobial Effects of Myrosinase Hydrolysis Products Derived from Glucosinolates Isolated fromPlants (Basel, Switzerland) · 2024Article
- Cleomin Exerts Acute Antinociceptive Effects in Mice via GABAPharmaceuticals (Basel, Switzerland) · 2023Article
- Article
- Glucosinolates, a natural chemical arsenal: More to tell than the myrosinase story.Frontiers in microbiology · 2023Review
- Characterization of a Novel Myrosinase with High Activity from Marine BacteriumInternational journal of molecular sciences · 2022Article
- Review
- Assessment of Methodological Pipelines for the Determination of Isothiocyanates Derived from Natural Sources.Antioxidants (Basel, Switzerland) · 2022Review
- Glucosinolates: Natural Occurrence, Biosynthesis, Accessibility, Isolation, Structures, and Biological Activities.Molecules (Basel, Switzerland) · 2020Review
- Pre- and Post-harvest Factors Affecting Glucosinolate Content in Broccoli.Frontiers in nutrition · 2020Review
- Atypical Myrosinase as a Mediator of Glucosinolate Functions in Plants.Frontiers in plant science · 2019Review
- Identification and Characterization of Three Epithiospecifier Protein Isoforms inFrontiers in plant science · 2019Article
- Glucosinolate Content in Dormant and GerminatingFrontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary metabolism is characterized by an impressive structural diversity. Here, we have addressed the mechanisms underlying structural diversification upon damage-induced activation of glucosinolates, a group of thioglucosides found in the Brassicales. The classical pathway of glucosinolate activation involves myrosinase-catalyzed hydrolysis and rearrangement of the aglucone to an isothiocyanate. Plants of the Brassicaceae possess specifier proteins, i.e. non-heme iron proteins that promote the formation of alternative products by interfering with this reaction through unknown mechanisms. We have used structural information available for the thiocyanate-forming protein from Thlaspi arvense (TaTFP), to test the impact of loops protruding at one side of its β-propeller structure on product formation using the allylglucosinolate aglucone as substrate. In silico loop structure sampling and semiempirical quantum mechanical calculations identified a 3L2 loop conformation that enabled the Fe
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.