Evidence map›Paper›PMID 30900274›Full record

ArticleJPEN. Journal of parenteral and enteral nutrition2019

Intravenous Fish Oil and Serum Fatty Acid Profiles in Pediatric Patients With Intestinal Failure-Associated Liver Disease.

Margaret L Ong, Robert S Venick, Stephen B Shew, James C Y Dunn, Laurie Reyen, Tristan Grogan, Kara L Calkins

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JPEN. Journal of parenteral and enteral nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00969332 (Omegaven and Parenteral Nutrition Associated Cholestasis), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00969332 phase2terminatednot on this map

Omegaven and Parenteral Nutrition Associated Cholestasis

TypeinterventionalSponsorUniversity of California, Los AngelesRan2009 to 2019Enrolled62ConditionsCholestasisArmsOmegaven
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Margaret L OngDepartment of Pediatrics, David Geffen School of Medicine UCLA, Mattel Children's Hospital at UCLA, Los Angeles, California, USA.
Robert S VenickDivision of Gastroenterology, Department of Pediatrics, David Geffen School of Medicine UCLA, Mattel Children's Hospital at UCLA, Los Angeles, California, USA.
Stephen B ShewDivision of Pediatric Surgery, Department of Surgery, Stanford University, Palo Alto, California, USA.
James C Y DunnDivision of Pediatric Surgery, Department of Surgery, Stanford University, Palo Alto, California, USA.
Laurie ReyenDivision of Gastroenterology, Department of Pediatrics, David Geffen School of Medicine UCLA, Mattel Children's Hospital at UCLA, Los Angeles, California, USA.
Tristan GroganDepartment of Medicine, David Geffen School of Medicine UCLA, Los Angeles, California, USA.
Kara L CalkinsDivision of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine UCLA, Mattel Children's Hospital at UCLA, Los Angeles, California, USA.
Mattel Children's Hospital · USStanford University · USUniversity of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
UCLA Clinical and Translational Science InstituteKL2TR000122 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$4.5M
NCATS NIH HHS KL2 TR000122NCATS NIH HHS KL2 TR001882NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NICHD NIH HHS L40 HD089253
6 · The paper itself

Abstract

backgroundIntravenous fish oil (FO) treats pediatric intestinal failure-associated liver disease (IFALD). There are concerns that a lipid emulsion composed of ω-3 fatty acids will cause an essential fatty acid deficiency (EFAD). This study's objective was to quantify the risk for abnormal fatty acid concentrations in children treated with FO.

methodsInclusion criteria for this prospective study were children with intestinal failure. Intravenous soybean oil (SO) was replaced with FO for no longer than 6 months. Serum fatty acids were analyzed using linear and logistic models, and compared with age-based norms to determine the percentage of subjects with low and high concentrations.

resultsSubjects (n = 17) started receiving FO at a median of 3.6 months (interquartile range 2.4-9.6 months). Over time, α-linolenic, linoleic, arachidonic, and Mead acid decreased, whereas docosahexaenoic and eicosapentaenoic acid increased (P < 0.001 for all). Triene-tetraene ratios remained unchanged (P = 1). Although subjects were 1.8 times more likely to develop a low linoleic acid while receiving FO vs SO (95% CI: 1.4-2.3, P < 0.01), there was not a significant risk for low arachidonic acid. Subjects were 1.6 times more likely to develop high docosahexaenoic acid while receiving FO vs SO; however, this was not significant (95% CI: 0.9-2.6, P = 0.08).

conclusionIn this cohort of parenteral nutrition-dependent children, switching from SO to FO led to a decrease in essential fatty acid concentrations, but an EFAD was not evident. Low and high levels of fatty acids developed. Further investigation is needed to clarify if this is clinically significant.

Indexed as

8,11,14-Eicosatrienoic AcidArachidonic AcidDocosahexaenoic AcidsEicosapentaenoic AcidFat Emulsions, IntravenousFatty AcidsFatty Acids, EssentialFatty Acids, Omega-3FemaleFish OilsHumansInfantIntestinal DiseasesLinoleic AcidLiver DiseasesMale8,11,14-Eicosatrienoic AcidArachidonic AcidDocosahexaenoic AcidsEicosapentaenoic AcidFat Emulsions, IntravenousFatty AcidsFatty Acids, EssentialFatty Acids, Omega-3Fish OilsLinoleic Acidmead acidSoybean Oilfatty acidsintestinal failurelipidspediatrics

Identifiers

PMID30900274
PMCPMC6720103
OpenAlexW2925153168

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.