ArticleGenes & genomics2019
Evolutionary and functional implications of 3' untranslated region length of mRNAs by comprehensive investigation among four taxonomically diverse metazoan species.
Article in Genes & genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 13 citations in OpenAlex.
- Dissecting non-B DNA structural motifs in untranslated regions of eukaryotic genomes.Genomics & informatics · 2024Article
- Chromosome-Level Assembly and Annotation of the Pearly Heath Coenonympha arcania Butterfly Genome.Genome biology and evolution · 2024Article
- Predictive modeling of oocyte maternal mRNA features for five mammalian species reveals potential shared and species-restricted regulators during maturation.Physiological genomics · 2024Article
- 3'UTR Diversity: Expanding Repertoire of RNA Alterations in Human mRNAs.Molecules and cells · 2023Review
- Symbiosis preservation: Putative regulation of fatty acyl-CoA reductase by miR-31a within the symbiont harboring bacteriome through tsetse evolution.Frontiers in microbiology · 2023Article
- New insights into genome annotation in Podospora anserina through re-exploiting multiple RNA-seq data.BMC genomics · 2022Article
- Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus.Neurobiology of aging · 2021Article
- PINK1: Multiple mechanisms of neuroprotection.International review of movement disorders · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn eukaryotic organisms, it has been well acknowledged that 3' untranslated regions (3' UTRs) of mRNA are actively involved in post-transcriptional regulations of gene expression. Although both shortening and lengthening of 3' UTRs of specific candidate genes were explicitly documented to have functional consequences, landscape of 3' UTR lengths in relation to evolutionary dynamics and biological meanings remains to be elucidated when large-scale data become available.
objectivesThe primary objective of this study was to revealed different inter- and intra-species patterns on length distribution of 3' UTRs in comparison with 5' UTRs and coding regions.
methodsIn the present study, we investigated 3' UTR lengths in a highly curated set of 57,135 mRNA sequences among four well-studied and taxonomically diverse metazoan species (fruit fly, zebrafish, mouse and human).
resultsThe average length ratio of 3'-5' UTRs considerably increased from fruit fly (twofold) to human (fivefold). Moreover, genes can be characterized by the obviously different patterns of evolutionary change on 3' UTR lengths. By utilizing the Gene Ontology annotations, genes with differential lengths of 3' UTRs were suggested to have the divergent functional implications. In human, we further revealed that ubiquitously transcribed genes had higher median lengths of 3' UTRs than the genes of tissue-restricted expressions.
conclusionWe conducted a comprehensive analysis and provided an overview regarding 3' UTRs biology of mRNAs in animals, whereas the mechanistic explanations of 3' UTRs length variation in correlation to regulation of gene expression still remain to be further studied.
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