Evidence map›Paper›PMID 30900099›Full record

SynthesisClinical and experimental medicine2019

The value of four imaging modalities in diagnosing lymph node involvement in rectal cancer: an overview and adjusted indirect comparison.

Ya Gao, Jipin Li, Xueni Ma, Jiancheng Wang, Bo Wang, Jinhui Tian, Gen Chen

Abstract readComparative StudyEvaluation StudySystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical and experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Rectal cancer: a methodological approach to matching PET/MRI to histopathology.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020
    Trial
  6. Indocyanine green-guided robotic-assisted mesorectal lymphadenectomy for high-risk T1 rectal carcinoma: Preliminary results of a prospective cohort study (IDEAL stage 2a).Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Contrast-enhanced endoscopic ultrasound for swollen lymph nodes.Journal of medical ultrasonics (2001) · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ya GaoEvidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, 730000, China.
Jipin LiThe Second Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Xueni MaThe Second Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Jiancheng WangGansu Provincial Hospital, Lanzhou, 73000, China.
Bo WangDepartment of Nursing, Rehabilitation Center Hospital of Gansu Province, Lanzhou, 730000, China.
Jinhui TianEvidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, 730000, China. tianjh@lzu.edu.cn.ORCID http://orcid.org/0000-0002-0054-2454
Gen ChenPathogens Biology Institute, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, 730000, China. chengen@lzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several systematic reviews have investigated the accuracy of imaging modalities for lymph node involvement of rectal cancer, but there are considerable differences in conclusions. This overview aimed to assess the methodological and reporting quality of systematic reviews that evaluated the diagnostic value of imaging modalities for lymph node involvement in patients with rectal cancer and to compare the diagnostic value of different modalities for lymph node involvement. The PubMed, EMBASE, Cochrane Library and Chinese Biomedicine Literature were searched to identify relevant systematic reviews. The methodological quality was assessed using the AMSTAR checklist, and the reporting quality was assessed using PRISMA-DTA checklist. The indirect comparison was conducted to compare the accuracy of different imaging modalities. Seven systematic reviews involving 353 primary studies were included. The median (Range) AMSTAR scores were 6.0 (4.0-9.0); the median (Range) PRISMA-DTA scores were 18.0 (11.0-23.0). Sensitivity of MRI [0.69 (95% CI 0.63, 0.77)] was significantly higher than that of ERUS [0.57 (95% CI 0.53, 0.62)]. Specificity of ERUS [0.80 (95% CI 0.77, 0.83)] was significantly higher than that of CT [0.72 (95% CI 0.67, 0.78)]. Positive likelihood ratio of EUS [3.04 (95% CI 2.75, 3.36)] was significantly higher than that of CT [2.21 (95% CI 1.69, 2.90)]. EUS had better diagnostic value than CT and ERUS in the diagnosis of lymph node involvement. Compared with CT and ERUS, MRI was more sensitive. EUS and MRI had comparable diagnostic accuracy, but no modality was proved to be particularly accurate.

Indexed as

HumansLymph NodesMagnetic Resonance ImagingRectal NeoplasmsSensitivity and SpecificityTomography, X-Ray ComputedUltrasonographyDiagnostic accuracyImaging modalityLymph node involvementOverviewRectal cancer

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.