Evidence map›Paper›PMID 30900095›Full record

ArticleJournal of clinical immunology2019

Severe Transitory Neonatal Neutropenia Associated with Maternal Autoimmune or Idiopathic Neutropenia.

Julie Seguier, Vincent Barlogis, Laure Croisille, Marie Audrain, Mikael Ebbo, Blandine Beaupain, Benoit Meunier, Blandine Vallentin, Rodolphe Jean, Jean-Robert Harle and 2 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Julie SeguierAix-Marseille University, APHM, Médecine Interne Hôpital de la Timone, 264 rue Saint Pierre, 13385 cedex 5, Marseille, France. julie.seguier@ap-hm.fr.ORCID 0000-0002-0755-0748
Vincent BarlogisAix-Marseille University, APHM, Pédiatrie et hématologie pédiatrique Hôpital de la Timone, Marseille, France.
Laure CroisilleLaboratoire HLA, EFS Ile de France, Créteil, France.
Marie AudrainLaboratoire d'immunologie, Institut de biologie, CHU de Nantes, Nantes, France.
Mikael EbboAix-Marseille University, APHM, Médecine Interne Hôpital de la Timone, 264 rue Saint Pierre, 13385 cedex 5, Marseille, France.
Blandine BeaupainService d'hématologie pédiatrique, Hôpital Trousseau, APHP, Paris, France.
Benoit MeunierAix-Marseille University, APHM, Médecine Interne Hôpital de la Timone, 264 rue Saint Pierre, 13385 cedex 5, Marseille, France.
Blandine VallentinAix-Marseille University, APHM, Pédiatrie et hématologie pédiatrique Hôpital de la Timone, Marseille, France.
Rodolphe JeanAix-Marseille University, APHM, Médecine Interne Hôpital de la Conception, Marseille, France.
Jean-Robert HarleAix-Marseille University, APHM, Médecine Interne Hôpital de la Timone, 264 rue Saint Pierre, 13385 cedex 5, Marseille, France.
Jean DonadieuService d'hématologie pédiatrique, Hôpital Trousseau, APHP, Paris, France.
Nicolas SchleinitzAix-Marseille University, APHM, Médecine Interne Hôpital de la Timone, 264 rue Saint Pierre, 13385 cedex 5, Marseille, France.
Aix-Marseille Université · FRSorbonne Université · FRCentre Hospitalier Universitaire de Nantes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeonatal immune neutropenia is observed in rare cases in newborns from mothers with idiopathic or autoimmune neutropenia, secondary to passive transfer of maternal granulocyte auto-antibodies.

methodsWe performed a literature review and report four supplementary cases from the French registry of neutropenia.

resultsOnly 14 cases (11 mothers, 14 newborns) have been reported. Granulocyte aggregation (GAT) and granulocyte indirect immunofluorescence test (GIFT) are the recommended laboratory procedures for antibody detection. Monoclonal antibody-specific immobilization of granulocyte antigens (MAIGA)-confirmed antibody specificity. Antibody detection in newborns is not generally possible owing to extreme neutropenia. In half of the cases autoantibodies against neutrophils (AAN) were positive in maternal sera (7 out of 11). In some newborns tested, IgG

conclusionsFrom the few cases reported so far it is impossible to draw any conclusions regarding frequency, risk factors, and outcome, but the overall prognosis for newborns seems good. Because it can be associated with potentially severe neonatal infections, autoimmune neutropenia in childbearing mothers should be closely monitored in collaboration with gynecologists and pediatricians.

Indexed as

NeutropeniaPregnancy Complications, HematologicAdultAutoantibodiesFemaleFranceGranulocyte Colony-Stimulating FactorGranulocytesHumansInfant, NewbornInfectionsLeukocyte CountMaleMothersPregnancyAutoantibodiesGranulocyte Colony-Stimulating FactorAnti-neutrophil antibodyAutoimmune neutropeniaNeonatal neutropeniaTransitory neutropenia

Identifiers

PMID30900095
OpenAlexW2925037605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.