ArticleClinical rheumatology2019
Ankylosing spondylitis is associated with aberrant DNA methylation of IFN regulatory factor 8 gene promoter region.
Article in Clinical rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.Molecular biotechnology · 2026Article
- From advanced imaging to molecular insights: the state of the art in omics for axial spondyloarthritis.Therapeutic advances in musculoskeletal disease · 2025Review
- Aberrant DNA Methylation Profile of Dickkopf-1 in Ankylosing Spondylitis.Biochemical genetics · 2024Article
- Application of methylation in the diagnosis of ankylosing spondylitis.Clinical rheumatology · 2024Review
- An Experimental Animal Study: Electroacupuncture Facilitates Antiviral Immunity Against Hepatitis B Virus Through the IFN-γ/JAK/STAT Axis.Journal of inflammation research · 2024Article
- DNA methylation of DKK-1 may correlate with pathological bone formation in ankylosing spondylitis.Immunity, inflammation and disease · 2023Article
- DNA methylation and transcription of the FOXO3a gene are associated with ankylosing spondylitis.Clinical and experimental medicine · 2023Article
- DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis.Genes and immunity · 2023Article
- Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis.Arthritis research & therapy · 2022Article
- The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.Frontiers in immunology · 2022Article
- Association of methylation level and transcript level in TRAF5 gene with ankylosing spondylitis: a case-control study.Genes and immunity · 2021Article
- The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis.Frontiers in cell and developmental biology · 2021Review
- Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis.Arthritis research & therapy · 2019Review
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo investigate the role of methylation levels of the IFN regulatory factor 8 (IRF8) gene promoter in the development of ankylosing spondylitis (AS).
methodsIn this study, we compared the methylation levels of the IRF8 gene promoter between 99 AS patients and 99 healthy controls using MethylTarget approach. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was performed to compare the mRNA levels of the IRF8 gene in the other 19 AS patients and 19 healthy controls.
resultsDifferential methylation was found in 91 CpG sites of the IRF8 gene promoter, and 4 CpG regions were highly methylated in AS patients compared to healthy controls (p < 0.05). In the verification stage, we found that the mRNA levels of the IRF8 gene in AS patients were significantly lower than that in controls (AS 0.77 (0.39-1.74), P = 0.038). Positive correlations between methylation of the IRF8 gene and the duration of disease, BASFI, and ESR were observed in AS patients.
conclusionsWe found a significant hypermethylation of the IRF8 gene promoter and a downregulation of the mRNA levels of the IRF8 gene in AS patients. This suggests that aberrant methylation of the IRF8 gene promoter may probably contribute to the development and pathogenesis of AS through regulating the expression of mRNA.
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