Evidence map›Paper›PMID 30900021›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

Sarcoidosis of the paranasal sinuses.

Thorsten Send, Izabela Tuleta, Tim Koppen, Thore Thiesler, Klaus W Eichhorn, Mattis Bertlich, Friedrich Bootz, Mark Jakob

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. InvasiveIDCases · 2021
    Article
  5. Phenotypes of Chronic Rhinosinusitis.The journal of allergy and clinical immunology. In practice · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Thorsten SendDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany. thorsten.send@ukbonn.de.ORCID http://orcid.org/0000-0001-6105-7121
Izabela TuletaDepartment of Internal Medicine-Cardiology, University of Munster, Munster, Germany.
Tim KoppenDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
Thore ThieslerDepartment of Pathology, University of Bonn, Bonn, Germany.
Klaus W EichhornDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
Mattis BertlichDepartment of Otorhinolaryngology, Munich University (LMU), Munich, Germany.
Friedrich BootzDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
Mark JakobDepartment of Otorhinolaryngology, Munich University (LMU), Munich, Germany.
University of Bonn · DELudwig-Maximilians-Universität München · DEUniversity of Göttingen · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSarcoidosis is a chronic disease, which predominantly affects the lung. Since sinonasal sarcoidosis is rare, little is known about the sarcoidosis manifestation at this site. Therefore, the aim of our study was to detect the prevalence of sinonasal sarcoidosis, its clinical occurrence, diagnosis, and therapy.

methodsThe database of all patients having visited the otorhinolaryngology departments of the universities in Göttingen and in Bonn between 2003 and 2016 was searched for the diagnosis of sinonasal sarcoidosis.

resultsThirteen patients with a biopsy-proven sinonasal sarcoidosis were identified. Most patients presented non-specific clinical symptoms, which are also found in acute and chronic sinusitis. None of the patients was suspected to have sinonasal sarcoidosis by the ENT doctor before histological validation. The mean diagnostic delay was 262 (± 195) days. An additional pulmonary involvement was detected in four of six patients.

conclusionsSinonasal sarcoidosis is presenting with heterogeneous clinical presentations. An early biopsy of granulomatous lesions is mandatory. A multidisciplinary approach is needed to exclude serious lung or heart manifestations, because even asymptomatic organ involvement is possible. A CT-scan may be useful even if unspecific. Local or systemic therapy has to be prepared individually using local and systemic corticosteroids, antimetabolites, or anti-TNF-alpha.

Indexed as

Paranasal Sinus DiseasesParanasal SinusesSarcoidosisBiopsyDelayed DiagnosisFemaleGermanyHumansMaleMiddle AgedPatient Care ManagementTomography, X-Ray ComputedExtrapulmonary sarcoidosisGranulomatous diseaseParanasal sinusSarcoidosisSinonasal sarcoidosis

Identifiers

PMID30900021
OpenAlexW2922603610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.