Evidence map›Paper›PMID 30899873›Full record

ArticleKidney international reports2019

Impact of Induction Therapy on Circulating T Follicular Helper Cells and Subsequent Donor-Specific Antibody Formation After Kidney Transplant.

Camila Macedo, Kevin Hadi, John Walters, Beth Elinoff, Marilyn Marrari, Adriana Zeevi, Bala Ramaswami, Geetha Chalasani, Douglas Landsittel, Adele Shields and 4 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. T-cell receptor sequencing reveals selected donor-reactive CD8American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  4. Article
  5. Article
  6. T cell depletion increases humoral response by favoring T follicular helper cells expansion.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Camila MacedoThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Kevin HadiThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
John WaltersThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Beth ElinoffThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Marilyn MarrariThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Adriana ZeeviThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Bala RamaswamiThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Geetha ChalasaniThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Douglas LandsittelThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Adele ShieldsDivision of Transplantation, University of Cincinnati, Cincinnati, Ohio, USA.
Rita AllowayDivision of Nephrology, University of Cincinnati, Cincinnati, Ohio, USA.
Fadi G LakkisThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
E Steve WoodleDivision of Transplantation, University of Cincinnati, Cincinnati, Ohio, USA.
Diana MetesThomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USUniversity of Cincinnati · USUniversity of Pittsburgh Medical Center · US

Funding

Diversity of TFH cells and DSA generation after kidney transplantationR01AI130010 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI METES, DIANA M · 2017 to 2021
$3.4M
T and B cell Homeostasis After Induction Therapy in Kidney TransplantationR01AI096553 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKKIS, FADI G. · 2011 to 2014
$1.4M
Contribution of TFH and of TREG cells to DSA generation in sensitized KTx recipientsR21AI116746 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI METES, DIANA M · 2015 to 2016
$415k
NIAID NIH HHS R01 AI096553NIAID NIH HHS R01 AI130010NIAID NIH HHS R21 AI116746
6 · The paper itself

Abstract

introductionThe cellular events that contribute to generation of donor-specific anti-HLA antibodies (DSA) post-kidney transplantation (KTx) are not well understood. Characterization of such mechanisms could allow tailoring of immunosuppression to benefit sensitized patients.

methodsWe prospectively monitored circulating T follicular helper (cT

resultsBefore KTx, patients displayed comparable levels of resting, central memory cT

conclusionInduction therapy distinctly shapes cT

Indexed as

donor-specific anti-HLA antibodykidney transplantationT follicular helper cellsthymoglobulin

Identifiers

PMID30899873
PMCPMC6409398
OpenAlexW2904251490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.