ArticleKidney international reports2019
Serum Creatinine in Pregnancy: A Systematic Review.
Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07068022 (Development and Validation of an Obstetric Organ Dysfunction Score to Predict Mortality in Intensive Care Unit), which is not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development and Validation of an Obstetric Organ Dysfunction Score to Predict Mortality in Intensive Care Unit: A Multicenter, Prospective, Cohort Study
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Clinical practice guideline on pregnancy and renal disease.BMC nephrology · 2019Guideline
- Assessment of point-of-care creatinine testing in pregnancy: a prospective cohort study in Sierra Leone.The Lancet regional health. Africa · 2026Article
- Zinc regulates the balance of specific gut microbiota through MTF1/Nrf2 and mitigates ferroptosis through activation of PINK1/Parkin/mitophagy via the gut-kidney axis in sepsis-associated acute kidney injury in pregnant mice.Apoptosis : an international journal on programmed cell death · 2026Article
- Pregnancy outcomes and risk factors analysis in patients with chronic kidney disease: a nested case-control study.BMC pregnancy and childbirth · 2026Article
- Comparison of estimated glomerular filtration rate equations on prediction of mortality, kidney failure and acute kidney injury.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Pregnancy-associated acute kidney injury - consensus report of the 32nd Acute Disease Quality Initiative workgroup.Nature reviews. Nephrology · 2025Article
- The impact of maternal chronic stress on spontaneous preterm birth: evidence from a Chinese cohort study.BMC pregnancy and childbirth · 2025Article
- Article
- Changes in serum creatinine during and after pregnancy in female patients with or without chronic kidney disease: an observational study in UK primary care data.Journal of nephrology · 2025Article
- NephroCheck AKI risk scores (TIMP-2 and IGFBP7) in pregnancy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Association Between Maternal Creatinine to Body Weight Ratio and Small/Large for Gestational Age Newborns Among 11,734 Chinese Women.Journal of epidemiology and global health · 2025Observational
- The effect of pregnancy on the population pharmacokinetics of levofloxacin in South Africans with rifampicin-resistant tuberculosis.Antimicrobial agents and chemotherapy · 2025Article
- Recurrence of preeclampsia is common, even during rigorously controlled multidisciplinary follow-up: a pilot experience.Clinical kidney journal · 2025Article
- Incidence and clinical outcomes of pregnancy-related acute kidney injury (PrAKI) in preeclampsia-complicated pregnancies in Saudi Arabia: a single-center experience.Journal of nephrology · 2025Article
- The role of sex and gender in acute kidney injury-consensus statements from the 33rd Acute Disease Quality Initiative.Kidney international · 2025Article
- Pregnancy as a Window to Current and Future Kidney Health-An Opportunity.Kidney international reports · 2025Article
- A recursive embedding and clustering technique for unraveling asymptomatic kidney disease using laboratory data and machine learning.Scientific reports · 2025Article
- Second Trimester Kidney Function and Adverse Pregnancy Outcomes among Patients with Lupus.Kidney360 · 2025Article
- Defining normal serum creatinine in pregnancy-results from the AKID UK prospective cohort study.Clinical kidney journal · 2025Article
- Maternal Mortality due to Pregnancy-Related Acute Kidney Injury (PRAKI); A Study of the Epidemiological Factors and Possible Solutions.Journal of obstetrics and gynaecology of India · 2025Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
introductionStandard assessment of renal function in pregnancy is by measurement of serum creatinine concentration yet normal gestational ranges have not been established. The aim of this systematic review was to define the difference in serum creatinine in a healthy pregnancy compared with concentrations in nonpregnant women to facilitate identification of abnormal kidney function in pregnancy.
methodsMedline, PubMed, Embase, Web of Science, theses, key obstetric texts, and conference proceedings were searched to July 2017. Eligible studies included quantification of serum creatinine concentration in a pregnant cohort, with either a reported local laboratory reference range or matched quantification in a nonpregnant cohort. The outcomes of interest were the mean and upper reference limits for creatinine in pregnancy, measured as a ratio of pregnant:nonpregnant values. Study heterogeneity was examined by meta-regression analysis.
resultsForty-nine studies were identified. Data synthesis included 4421 serum creatinine values in pregnancy, weighted according to cohort size. Mean values for serum creatinine in pregnancy were 84%, 77%, and 80% of nonpregnant mean values during the first, second, and third trimesters, respectively. The 97.5th centile (upper limit of the 95% reference range) for serum creatinine in pregnancy was 85%, 80%, and 86% of the nonpregnant upper limit in sequential trimesters.
conclusionBased on a nonpregnant reference interval of 45-90 μmol/l (0.51-1.02 mg/dl), a serum creatinine of >77 μmol/l (0.87 mg/dl) should be considered outside the normal range for pregnancy. Future work can use this value to explore correlation of adverse pregnancy outcomes with serum creatinine concentration. PROSPERO registration: CRD42017068446.
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