ArticleHeliyon2019
Autonomic maturation from birth to 2 years: normative values.
Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Heart Rate Variability Analysis to Evaluate Autonomic Nervous System Maturation in Neonates: An Expert Opinion.Frontiers in pediatrics · 2022Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Maternal singing sustains preterm hospitalized newborns' autonomic nervous system maturation: an RCT.Pediatric research · 2024Trial
- A Protocol to Acquire Infant Heart Rate Variability in the Rohingya Camps and Surrounding Communities in Cox's Bazar, Bangladesh.Psychophysiology · 2026Article
- Early Maturation of Heart Rate Variability in Very Preterm Infants Depends on Neonatal Factors and Is Associated With Neurodevelopmental Risk.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- High-salt intake alters autonomic maturation trajectories assessed by an HRV-based ANS Age Index in rats.Frontiers in physiology · 2026Article
- Systematic Review on HRV Reference Values.Journal of cardiovascular development and disease · 2025Review
- Reference ranges of gender- and age-related heart rate variability parameters in Russian children.Scientific reports · 2025Article
- Feasibility of wearable monitors to detect heart rate variability in children with hand, foot and mouth disease.BMC infectious diseases · 2024Observational
- Exposure to prenatal stressors and infant autonomic nervous system regulation of stress.Stress (Amsterdam, Netherlands) · 2024Article
- Sympathetic nervous system activity and pain-related response indexed by electrodermal activity during the earliest postnatal life in healthy term neonates.Physiological research · 2023Article
- Bedside tracking of functional autonomic age in preterm infants.Pediatric research · 2023Article
- Comparing Full and Pre-Term Neonates' Heart Rate Variability in Rest Condition and during Spontaneous Interactions with Their Parents at Home.Healthcare (Basel, Switzerland) · 2023Article
- Interactive synchrony and infants' vagal tone as an index of emotion regulation: associations within each mother- and father-infant dyad and across dyads.Frontiers in psychology · 2023Article
- When the Mind Comes to Live Inside the Body: The Ontogeny of the Perceptual Control Clock.Current neuropharmacology · 2023Article
- Article
- Osteopathic Manipulative Treatment Regulates Autonomic Markers in Preterm Infants: A Randomized Clinical Trial.Healthcare (Basel, Switzerland) · 2022Article
- Neonatal heart rate variability: a contemporary scoping review of analysis methods and clinical applications.BMJ open · 2021Article
- Changes in the Time-Domain of Heart Rate Variability and Corticosterone after Surgical Trauma to the Nasal Septum in Rats.Doklady. Biochemistry and biophysics · 2021Article
- Maturation of the Cardiac Autonomic Nervous System Activity in Children and Adolescents.Journal of the American Heart Association · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile heart rate variability (HRV) constitutes a relevant non-invasive tool to assess the autonomic nervous system (ANS) function with recognized diagnostic or therapeutic implications, there is still a lack of established data on maturation of autonomic control of heart rate during the first months of life. The Autonomic Baby Evaluation (
methodsHeart rate variability analysis was carried out in 271 full-term newborns (mean gestational age 39 wGA + 5 days) from reliable polysomnographic recordings at 0 (n = 270) and 6 (n = 221) months and from a 24-hour ambulatory electrocardiogram (ECG) at 12 (n = 210), 18 (n = 197), and 24 (n = 190) months. Indices of HRV analysis were calculated through the
resultsIndices are dissociated according a temporal, geometrical, frequency, Poincaré, empirical mode decomposition, fractal, Chaos and DC/AC and entropy analysis. Each index is presented for five different periods of time, 0, 6, 12, 18 and 24 months and with smoothed values in the 3rd, 10th, 50th, 90th and 97th percentiles. Data are also presented for the full cohort and individualized by sex to account for gender variability. DISCUSSION &
conclusionThe physiological autonomic maturation profile from birth to 2 years in a healthy population of term neonates results in a fine-tuning autonomic maturation underlying progressively a new equilibrium and privileging the parasympathetic activity over the sympathetic activity.
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