ArticleTrauma surgery & acute care open2019
Nationwide cohort study of independent risk factors for acute respiratory distress syndrome after trauma.
Article in Trauma surgery & acute care open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- A deep learning-based model combining quantitative parameters of initial chest computed tomography and clinical variables for the prediction of posttraumatic acute respiratory distress syndrome.Quantitative imaging in medicine and surgery · 2026Article
- Development and Validation of a Multidimensional Predictive Model for 28-Day Mortality in Patients with Post-Traumatic Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2026Article
- AR-R17779, an agonist of alpha-7 nicotinic acetylcholine receptor, attenuates trauma-induced lung epithelial glycocalyx injury by suppressing macrophage proinflammatory activity.The journal of trauma and acute care surgery · 2026Article
- Early Prediction of Acute Respiratory Distress Syndrome in Critically Ill Polytrauma Patients Using Balanced Random Forest ML: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Significance of a hypotensive episode following traumatic injury: A retrospective observational study.World journal of critical care medicine · 2025Article
- An Analysis of the Association of Whole Blood Transfusion With the Development of Acute Respiratory Distress Syndrome.Critical care medicine · 2025Article
- Surgical stabilization of rib fractures in conjunction with veno-venous ECMO for traumatic chest wall injury: a multi-institutional case series from the Chest Wall Injury Society (CWIS).Trauma surgery & acute care open · 2025Article
- Steroids in acute respiratory distress syndrome: A panacea or still a puzzle?World journal of critical care medicine · 2024Review
- [Risk factors for acute respiratory distress syndrome in patients with traumatic hemorrhagic shock].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Review
- Sex-Based Differences in Human Neutrophil Chemorepulsion.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Department of Defense Trauma Registry Infectious Disease Module Impact on Clinical Practice.Military medicine · 2022Review
- Association between trauma exposure and respiratory disease-A Mendelian randomization study.Frontiers in endocrinology · 2022Article
- Shoulder injuries in polytraumatized patients: an analysis of the TraumaRegister DGU®.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Radiomics score predicts acute respiratory distress syndrome based on the initial CT scan after trauma.European radiology · 2021Article
- Article
- Mortality prediction for patients with acute respiratory distress syndrome based on machine learning: a population-based study.Annals of translational medicine · 2021Article
- Club Cell Protein 16 Attenuates CD16Journal of immunology research · 2021Article
- Retrospective study on rib fractures: smoking and alcohol matter for mortality and complications.Trauma surgery & acute care open · 2021Article
- Natural and engineered chemokine (C-X-C motif) receptor 4 agonists prevent acute respiratory distress syndrome after lung ischemia-reperfusion injury and hemorrhage.Scientific reports · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe primary objective of this study was to evaluate the effect of specific direct and indirect factors that accounted, in trauma patients, for the development of acute respiratory distress syndrome (ARDS) and mortality in patients with ARDS.
methodsWe performed a retrospective cohort study of patients from the National Trauma Data Bank. Multilevel mixed-effects logistic regression was used with the development of ARDS as the primary and mortality in patients with ARDS as the secondary outcome measures. We compared trauma patients with versus without thoracic (direct) and extrathoracic (indirect) risk factors, using patient demographics, physiologic, and anatomic injury severity as covariates. Subset analysis was performed for patients with trauma-induced lung contusion (TILC) and for patients with minor (Injury Severity Score [ISS] ≤15) injury.
resultsA total of 2 998 964 patients were studied, of whom 28 597 developed ARDS. From 2011 to 2014, the incidence of ARDS decreased; however, mortality in patients with ARDS has increased. Predictors of ARDS included direct thoracic injury (TILC, multiple rib fractures, and flail chest), as well as indirect factors (increased age, male gender, higher ISS, lower Glasgow Coma Scale motor component score, history of cardiopulmonary or hematologic disease, and history of alcoholism or obesity). Patients with ARDS secondary to direct thoracic injury had a lower risk of mortality compared with patients with ARDS due to other mechanisms. DISCUSSION: Despite the decreasing incidence of trauma-induced ARDS, mortality in patients with ARDS has increased. Direct thoracic injury was the strongest predictor of ARDS. Knowing specific contributors to trauma-induced ARDS could help identify at-risk patients early in their hospitalization and mitigate the progression to ARDS and thereby mortality. LEVEL OF EVIDENCE: Prognostic study, level III.
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