Evidence map›Paper›PMID 30899675›Full record

ArticleToxicology reports2019

Reprogramming of CaCo2 colorectal cancer cells after using the complex of poly-(N-vinylpyrrolidone) with small non-coding RNAs.

Oxana V Klimenko, Mikhail Shtilman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. SelectiveToxicology reports · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Oxana V KlimenkoSID ALEX GROUP, LTD, Kyselova, 1185/2, Prague, 182 00, Czechia.
Mikhail ShtilmanDepartment of Biomaterials, D.I. Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow, 125047, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small non-coding RNAs control normal development and differentiation in the embryo. These regulatory molecules play a key role in the development of human diseases and are used often today for researching new treatments for different pathologies. In this study, CaCo2 colorectal adenocarcinoma cells were initially epigenetically reprogrammed and transformed into CD4+ cells with nano-sized complexes of amphiphilic poly-(N-vinylpyrrolidone) (

Indexed as

AGO2, argonaute 2Amphiphilic poly-(N-vinylpyrrolidone)BACH1, BTB domain and CNC homolog 1CaCo2 colorectal adenocarcinomaCD, cluster of differentiationDICER1, ribonuclease IIIDNMT1, DNA methyltransferase 1DTT, dithyothreitolERK1/2, extracellular signal regulated kinase ½FGF2, fibroblast growth factor 2GITR3A, glucocorticoid-induced TNFR-related proteinH3K9me3, tri-methyl lysine 9 of histone H3HILI, human piwiHMOX1, heme oxygenase 1HOXA10, homebox A10ICOS1B, inducible T-cell co-stimulatorIL, interleukiniPS, induced pluripotent stem cellsKIR1DL2, CD158b, expressed on natural killer cells and a subset of T cellsmiR, micro-RNAmiRNA-152MKI-67, marker of proliferation ki-67mTOR, mechanistic target of rapamycinOCT4, octamer-binding transcription factor 4piRNA-30074piR, piwi-interacting RNA, P-element induced wimpy testis interacting RNAPIWIL1, piwi-like protein 1PNVP, poly-(N-vinylpyrrolidone)Polymer carriersRB1, retinoblastoma 1ReprogrammingSncRNAs, small non-coding RNAsTE, transposon elementsTGFBR2, transforming growth factor beta receptor 2TNFRS6B, TNF receptor superfamily 6BTSS, transcriptional start sitesVMAF, musculoaponeurotic fibrosarcomaWnt-1, wingless type MMTV integration site family, member 1

Identifiers

PMID30899675
PMCPMC6405903

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.