ArticleJournal of clinical & translational endocrinology2019
Serum free thiols in type 2 diabetes mellitus: A prospective study.
Article in Journal of clinical & translational endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Serum redox markers in uncomplicated type 2 diabetes mellitus accompanied with abnormal iron levels.Central European journal of public health · 2023Article
- Plasma Free Thiol Levels during Early Sepsis Predict Future Renal Function Decline.Antioxidants (Basel, Switzerland) · 2022Article
- Serum free sulfhydryl status associates with new-onset chronic kidney disease in the general population.Redox biology · 2021Article
- The Effect of Lifestyle Intervention on Systemic Oxidative Stress in Women with Obesity and Infertility: A Post-Hoc Analysis of a Randomized Controlled Trial.Journal of clinical medicine · 2021Article
- Systemic Oxidative Stress, Aging and the Risk of Cardiovascular Events in the General Female Population.Frontiers in cardiovascular medicine · 2021Article
- Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population.Oxidative medicine and cellular longevity · 2021Article
- Oxidative stress is associated with suspected non-alcoholic fatty liver disease and all-cause mortality in the general population.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- Systemic Oxidative Stress Is Increased in Postmenopausal Women and Independently Associates with Homocysteine Levels.International journal of molecular sciences · 2020Article
- Hypomagnesemia in persons with type 1 diabetes: associations with clinical parameters and oxidative stress.Therapeutic advances in endocrinology and metabolism · 2020Article
- The Systemic Redox Status Is Maintained in Non-Smoking Type 2 Diabetic Subjects Without Cardiovascular Disease: Association with Elevated Triglycerides and Large VLDL.Journal of clinical medicine · 2019Article
- Antioxidant Supplements and Oxidative Stress: The debate extends to the Middle East.Sultan Qaboos University medical journal · 2019Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsOxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status.
methodsR-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6.7% (50 mmol/mol)) with a follow-up period of 1.2 years.
resultsIn the highest R-SH tertile patients were younger, more often men, had less microvascular complications, lower HbA1c and were more often treated nutritionally or with oral glucose-lowering drugs. Age- and sex adjusted hazard ratios for developing micro-, macro- or any complication plus death were 0.994, 0.992 and 0.993: even after adjustment for potential confounders. The Harrell's C statistic to predict microvascular complications or any complication plus death was higher in the models with R-SH than in those without R-SH.
conclusionsAlthough R-SH concentrations were associated with a favourable disease status, it did not add to the predictive capacity for long-term complications. Based on the current data R-SH seems unsuitable as a prognostic marker in T2DM.
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