ArticleNature biomedical engineering2018
Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging.
Article in Nature biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Oxygels: Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen.Advanced healthcare materials · 2026Article
- Radiotherapy beam tracking by dual-modality injectable fiducial marker for X-ray CT and Cherenkov luminescence imaging.Biomedical optics express · 2026Article
- Cherenkov light emission in external beam radiation therapy of the larynx.Journal of biomedical optics · 2025Article
- Optical-magnetic Imaging for Optimizing Lymphodepletion-TIL Combination Therapy in Breast Cancer.Molecular imaging and biology · 2025Article
- Multiscale local sparsity and prior learning algorithm for Cherenkov-excited luminescence scanned tomography reconstruction.Applied optics · 2025Article
- Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy.Frontiers in medicine · 2025Review
- Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.Chemical reviews · 2024Review
- Review of Cherenkov imaging technology advances in radiotherapy: single-photon-level imaging in high ambient light and radiation backgrounds.Biophotonics discovery · 2024Review
- Time-gated single-pixel imaging of Cherenkov emission from a medical linear accelerator.Optics letters · 2024Article
- Review of optical reporters of radiation effectsJournal of biomedical optics · 2023Review
- Biocompatible Phosphorescent OBiosensors · 2023Article
- Photon-limited Cherenkov imaging of radiation therapy dose.Optics letters · 2023Article
- Selfrec-Net: self-supervised deep learning approach for the reconstruction of Cherenkov-excited luminescence scanned tomography.Biomedical optics express · 2023Article
- X-ray Cherenkov-luminescence tomography reconstruction with a three-component deep learning algorithm: Swin transformer, convolutional neural network, and locality module.Journal of biomedical optics · 2023Article
- Image guidance for FLASH radiotherapy.Medical physics · 2022Article
- Cerenkov radiation-activated probes for deep cancer theranostics: a review.Theranostics · 2022Review
- High-Resolution pOInternational journal of radiation oncology, biology, physics · 2021Article
- Prior Compensation Algorithm for Cerenkov Luminescence Tomography From Single-View Measurements.Frontiers in oncology · 2021Article
- Review of in vivo optical molecular imaging and sensing from x-ray excitation.Journal of biomedical optics · 2021Review
- What Is the Meaning of an Oxygen Measurement? : Analysis of Methods Purporting to Measure Oxygen in Targeted Tissues.Advances in experimental medicine and biology · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Low signal-to-noise ratios and limited imaging depths restrict the ability of optical-imaging modalities to detect and accurately quantify molecular emissions from tissue. Here, by using a scanning external X-ray beam from a clinical linear accelerator to induce Cherenkov excitation of luminescence in tissue, we demonstrate in vivo mapping of the oxygenation of tumours at depths of several millimetres, with submillimetre resolution and nanomolar sensitivity. This was achieved by scanning thin sheets of the X-ray beam orthogonally to the emission-detection plane, and by detecting the signal via a time-gated CCD camera synchronized to the radiation pulse. We also show with experiments using phantoms and with simulations that the performance of Cherenkov-excited luminescence scanned imaging (CELSI) is limited by beam size, scan geometry, probe concentration, radiation dose and tissue depth. CELSI might provide the highest sensitivity and resolution in the optical imaging of molecular tracers in vivo.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.