SynthesisBMJ open gastroenterology2019
Moderately severe and severe acute pancreatitis : a systematic review of the outcomes in the USA and European Union-5.
Synthesis in BMJ open gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Long-term quality of life after acute pancreatitis: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024.Frontiers in medicine · 2025Pooled it
- Effect of a structured early rehabilitation program on long-term functional recovery, quality of life, and survival in patients with severe acute pancreatitis: a randomized controlled trial.BMC gastroenterology · 2026Trial
- Deep learning-based prediction of acute pancreatitis severity from abdominal CT with multicenter external validation.Radiology advances · 2026Article
- Liver and pancreatic fat fractions as predictors of disease severity in acute pancreatitis: an MRI IDEAL-IQ study.Abdominal radiology (New York) · 2025Article
- Cytomegalovirus Reactivation in Critically Ill Patients With Acute Necrotizing Pancreatitis.Open forum infectious diseases · 2025Article
- MRI and CT radiomics for the diagnosis of acute pancreatitis.European journal of radiology open · 2025Article
- Global incidence and mortality of pancreatitis in women of childbearing age from 1990 to 2021.Scientific reports · 2025Article
- Comparative Analysis of Laboratory Markers, Severity Scores, and Outcomes in 179 Patients with Severe Acute Pancreatitis.Biomedicines · 2025Article
- Early Prophylactic Anticoagulation and In-Hospital Mortality in Patients with Severe Acute Pancreatitis: A Retrospective Cohort Study.Open access emergency medicine : OAEM · 2025Article
- Shared Decision Making Is Important in the Management of Asymptomatic Diminutive Bile Duct Stones.Digestive diseases and sciences · 2024Article
- Predicting the severity of acute pancreatitis: Current approaches and future directions.Surgery open science · 2024Article
- Corticosteroids to Reduce Inflammation in Severe Pancreatitis (CRISP) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomized, placebo controlled clinical trial.Contemporary clinical trials · 2024Article
- Surgical decompression for the management of abdominal compartment syndrome with severe acute pancreatitis: A narrative review.World journal of gastrointestinal surgery · 2023Review
- Article
- Efficacy and safety of Dachaihu Decoction for acute pancreatitis: Protocol for a systematic review and meta-analysis.PloS one · 2023Article
- Optimal Timing and Outcomes of Minimally Invasive Approach in Acute Biliary Pancreatitis.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Anti-Inflammatory Effects and Molecular Mechanisms of Shenmai Injection in Treating Acute Pancreatitis: Network Pharmacology Analysis and Experimental Verification.Drug design, development and therapy · 2022Article
- Electroacupuncture at Acupoint ST36 (Zusanli) Improves Intestinal Motility Dysfunction Via Increasing the Proportion of Cholinergic Neurons in Rat Ileal Myenteric Ganglia after Severe Acute Pancreatitis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- C-Reactive Protein as a Predictor of Complicated Acute Pancreatitis: Reality or a Myth?Cureus · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe global incidence of hospitalisation due to acute pancreatitis (AP) has been rising in the recent decades. In the USA alone, there was a 13.2% increase between 2009 and 2012 compared with 2002-2005. There remains a lack of approved treatments to prevent disease progression, leaving many liable to developing complications that include multisystem organ failure (OF) and death. This therapeutic deficit raises questions about the scale of the current burden of illness (BOI) associated with severe forms of AP. The aim of the systematic literature review (SLR) was to assess clinical, humanistic, and economic outcomes associated with moderately severe AP (MSAP) and severe AP (SAP) in the USA and the European Union-5 (EU-5).
methodsSystematic searches were conducted in MEDLINE and Embase to identify studies published in English (between 2007 and 2017) that reported on the BOI of MSAP and/or SAP. Manual searches of 'grey' literature sources were also conducted.
resultsThe SLR identified 19 studies which indicated that 15%-20% of patients with AP progress to more severe forms of the disease, up to 10.5% of those with SAP require surgery for complications, and up to 40% die during hospitalisation. By contrast, there appears to be a lack of data on the extent to which SAP affects patients' quality of life.
conclusionThe available evidence clearly demonstrates that the current management for MSAP and SAP in the USA and EU-5 does not adequately meet patients' needs. Early identification and intervention for AP is crucial, given the evidence of high rates of morbidity and an associated economic burden that is considerable. Since many patients with the condition present to hospitals at a point when multisystem OF or death is highly likely, there is a particularly urgent need for effective treatment options to prevent disease progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.