ArticleAmerican journal of translational research2019
Long non-coding RNA SNHG7 promotes the fracture repair through negative modulation of miR-9.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Review
- Non-coding RNAs in osteoarthritis and osteoporosis-related hip fractures: molecular biomarkers for precision diagnosis and prognosis.Frontiers in endocrinology · 2025Review
- The Roles ofGenes · 2022Review
- [Regulation of long non-coding RNA in signal pathways related to osteogenic differentiation].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2022Article
- The Involvement of Long Non-Coding RNAs in Bone.International journal of molecular sciences · 2021Review
- Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth andOncology reports · 2021Article
- Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials.Frontiers in cell and developmental biology · 2021Review
- SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer.Cell cycle (Georgetown, Tex.) · 2020Article
- Long Non-Coding RNA SNHG7 Alleviates Oxygen and Glucose Deprivation/Reoxygenation-Induced Neuronal Injury by Modulating miR-9/SIRT1 Axis in PC12 Cells: Potential Role in Ischemic Stroke.Neuropsychiatric disease and treatment · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fracture is the most common disease in the orthopedics. Long non-coding small nucleolar RNA host gene 7 (SNHG7) has been confirmed to enhance cell proliferation and decrease cell apoptosis in many cancers. However, the role of SNHG7 in skeletal fracture remains largely to be elucidated. In the current study, we observed SNHG7 was down-regulated in femoral neck fracture tissues. In addition, SNHG7 knockdown inhibited proliferation and migration, induced apoptosis, reduced activity in osteoblast cells in vitro. Bioinformatics analysis revealed SNHG7 acts as a molecular sponge for miR-9 and MiR-9 directly targets with 3'-UTR of TGFBR2. Furthermore, SNHG7 knockdown repressed the TGF-β signaling pathway. Taken together, this study manifested SNHG7 promotes bone repair in femoral neck fracture, and may serve as a potential target for enhancing bone formation.
Indexed as
Identifiers
30899396PMC6413244W2984949318What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.