ArticleAmerican journal of translational research2019
Long noncoding RNA LINC01296 induces non-small cell lung cancer growth and progression through sponging miR-5095.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Assessment of biochemical recurrence of prostate cancer (Review).International journal of oncology · 2019Pooled it
- Mechanistic study of LINC01296 mediating TRIP13 regulation of neuroblastoma progression.Translational cancer research · 2025Article
- MiR-5095 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting CEACAM5.Scientific reports · 2025Article
- Unraveling the Pivotal Role of LncRNA DUXAP9 in Cancer: Current Progress and Future Perspectives.Current drug targets · 2025Review
- The Emerging Role of Long Non-coding RNA 01296 in Human Malignancies.Current molecular medicine · 2025Review
- LncRNA SNHG20 silencing inhibits hepatocellular carcinoma progression by sponging miR-5095 from MBD1.American journal of translational research · 2023Article
- LINC01296 promotes neuroblastoma tumorigenesis via the NCL-SOX11 regulatory complex.Molecular therapy oncolytics · 2022Article
- The role of long non-coding RNA LINC01296 in oral squamous cell carcinoma: a study based on bioinformatics analysis andJournal of Cancer · 2022Article
- LINC01207 promotes the progression of non-small cell lung cancer via regulating ARHGAP11A by sponging miR-525-5p.Cancer biomarkers : section A of Disease markers · 2022Article
- Article
- Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis.Journal of translational medicine · 2021Article
- Long Noncoding RNA MLK7-AS1 Promotes Non-Small-Cell Lung Cancer Migration and InvasionFrontiers in oncology · 2021Article
- Identification of long non-coding RNA signatures for squamous cell carcinomas and adenocarcinomas.Aging · 2020Article
- Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression.Oncology reports · 2020Article
- LncRNA H19 promotes odontoblastic differentiation of human dental pulp stem cells by regulating miR-140-5p and BMP-2/FGF9.Stem cell research & therapy · 2020Article
- LINC00511 promotes gastric cancer cell growth by acting as a ceRNA.World journal of gastrointestinal oncology · 2020Article
- MiR-29c-3p, a target miRNA of LINC01296, accelerates tumor malignancy: therapeutic potential of a LINC01296/miR-29c-3p axis in ovarian cancer.Journal of ovarian research · 2020Article
- LncRNA NNT-AS1 promotes non-small cell lung cancer progression through regulating miR-22-3p/YAP1 axis.Thoracic cancer · 2020Article
- Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells.Experimental gerontology · 2020Article
- Long Non-Coding RNA PVT1 Regulates BAMBI To Promote Tumor Progression In Non-Small Cell Lung Cancer By Sponging miR-17-5p.OncoTargets and therapy · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long noncoding RNAs (lncRNAs) played in authentic biological cell roles such as cell apoptosis, cycle, differentiation, development, migration and invasion. However, the expression pattern and function of a new lncRNA LINC01296 in non-small cell lung cancer (NSCLC) are unknown and need to be studied. In our study, we indicate that the expression of LINC01296 was overexpressed in NSCLC samples compared to adjacent non-tumor tissues. Ectopic expression of LINC01296 promoted NSCLC cell proliferation and migration. Moreover, we demonstrated that LINC01296 has a potential binding site for miR-5095 by using online program tool StarBase. Overexpression of LINC01296 inhibited the expression of miR-5095 in the A549 cell. Furthermore, the miR-5095 expression was downregulated in the NSCLC tissues than in the adjacent non-tumor tissues. In addition, we found that there is a negative correlation between miR-5095 expression and LINC01296 level in the NSCLC tissues. Overexpression of miR-5095 suppressed NSCLC cell proliferation and migration. Finally, we demonstrate that ectopic expression of LINC01296 promoted cell proliferation and migration via inhibiting miR-5095 expression. These results suggested that LINC01296 might act a role as an oncogene in the tumorigenesis and development of NSCLC.
Indexed as
Identifiers
30899389PMC6413248W2982027271What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.