ArticleAmerican journal of translational research2019
Herbacetin treatment remitted LPS induced inhibition of osteoblast differentiation through blocking AKT/NF-κB signaling pathway.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Herbacetin alleviates acute doxorubicin cardiotoxicity via regulating the ERK1/2-FOXO3a signaling pathway.Human cell · 2026Article
- Dysregulation of miR-106a-5p/PTEN axis associated with progression and diagnostic of postmenopausal osteoporosis.Journal of orthopaedic surgery and research · 2025Article
- Effects of low dietary calcium and lipopolysaccharide challenges on production performance, eggshell quality, and bone metabolism of laying hens.Frontiers in physiology · 2024Article
- Erxian herbal pair enhances bone formation in infected bone nonunion models and attenuates lipopolysaccharide-induced osteoblastinhibition by regulating miRNA-34a-5p.Bioengineered · 2022Article
- LIN28A alleviates inflammation, oxidative stress, osteogenic differentiation and mineralization in lipopolysaccharide (LPS)-treated human periodontal ligament stem cells.Experimental and therapeutic medicine · 2022Article
- miR-140-3p aggregates osteoporosis by targeting PTEN and activating PTEN/PI3K/AKT signaling pathway.Human cell · 2020Article
- Downregulation of microRNA-16-5p accelerates fracture healing by promoting proliferation and inhibiting apoptosis of osteoblasts in patients with traumatic brain injury.American journal of translational research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation, a common situation during the process of bone healing, is reported to play a negative role in bone regeneration. Up to date, therapeutic strategies for inflammation triggered inhibition of osteoblast differentiation are still limited. The aim of this study was to explore the potential roles and molecular mechanisms of Herbacetin in the process of osteoblast differentiation under LPS-mediated inflammatory environment. By using MC3T3-E1, C2C12 and primary mouse calvarial osteoblast (PMCO) cells as experimental models, we observed that LPS stimulation suppressed osteoblast differentiation via inhibiting alkaline phosphatase (ALP) activity and the expression of several osteoblastic genes (osterix, runx2 and osteocalcin). However, the negative role of LPS during osteoblast differentiation could be restored by Herbacetin treatment. Mechanistical studies revealed that Herbacetin treatment suppressed AKT activation and in turn blocked NF-κB signaling pathway. Furthermore, reactivating AKT by a selective PTEN inhibitor SF1670 suppressed the effect of Herbacetin. These data suggested that Herbacetin might play a protective role in osteoblast differentiation in MC3T3-E1/C2C12/PMCO cells under LPS stimulation.
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Identifiers
30899386PMC6413242W2991276971What OpenQuestion holds
Registered trials
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