Evidence map›Paper›PMID 30899379›Full record

ArticleAmerican journal of translational research2019

Exosomes from miRNA-126-modified ADSCs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation.

Wujun Geng, Hongli Tang, Shan Luo, Ya Lv, Dongdong Liang, Xianhui Kang, Wandong Hong

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 6 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 6 syntheses or guidelines pooled it, 182 citations in OpenAlex.

  1. Pooled it
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  3. Systematic review: Association between circulating microRNA expression & stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Pooled it
  4. Pooled it
  5. Pleiotropic Effects of Exosomes as a Therapy for Stroke Recovery.International journal of molecular sciences · 2020
    Pooled it
  6. Pooled it
  7. Review
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  9. Article
  10. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Article
  12. Article
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  19. MicroRNA-126 as an endogenous molecule for hypoxic/ischemic tolerance in neuroprotection.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  20. Review

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wujun GengDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Hongli TangDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Shan LuoDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Ya LvDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Dongdong LiangDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Xianhui KangDepartment of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, Zhejiang, China.
Wandong HongDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
Wenzhou Medical University · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although adipose derived stem cells (ADSCs) exert their therapeutic potential in ischemic stroke, the migration of ADSCs in injured area is not apparently observed after intravenous administration. ADSCs are an important source of exosomes which hold great promise as an endogenous drug delivery system for the treatment of cerebral ischemia given their ability to cross the blood-brain barrier. Here we investigated whether ADSCs-derived exosomes mediated miRNAs transfer and thus promoted neurological recovery after stroke. We first proved that miR-126 levels were reduced in patients' plasma with acute ischemic stroke and in rat plasma and brain tissue after ischemia. To test the effect of exosomal miR-126, we employed overexpression and knock-down technologies to up-regulate or inhibit miR-126 level in ADSCs and thus acquired miR-126

Indexed as

ADSCsexosomesmiR-126neurogenesisstroke

Identifiers

PMID30899379
PMCPMC6413259
OpenAlexW2987384074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.