Evidence map›Paper›PMID 30899262›Full record

ArticleFrontiers in immunology2019

Baokun He, Thomas K Hoang, Xiangjun Tian, Christopher M Taylor, Eugene Blanchard, Meng Luo, Meenakshi B Bhattacharjee, Jasmin Freeborn, Sinyoung Park, Jacob Couturier and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it, 179 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Indole-3-carboxaldehyde fromGut microbes · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Gut microbes · 2025
    Review
  15. Article
  16. Review
  17. ProbioticAntioxidants (Basel, Switzerland) · 2025
    Article
  18. Review
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Baokun HeDivision of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Thomas K HoangDivision of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Xiangjun TianDepartment of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Christopher M TaylorDepartment of Microbiology, Immunology & Parasitology, Louisiana State University, School of Medicine, New Orleans, LA, United States.
Eugene BlanchardDepartment of Microbiology, Immunology & Parasitology, Louisiana State University, School of Medicine, New Orleans, LA, United States.
Meng LuoDepartment of Microbiology, Immunology & Parasitology, Louisiana State University, School of Medicine, New Orleans, LA, United States.
Meenakshi B BhattacharjeePathology and Laboratory Medicine, University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Jasmin FreebornDivision of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Sinyoung ParkDivision of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Jacob CouturierInternal Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
John William LindseyNeurology, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Dat Q TranDivision of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Jon Marc RhoadsDivision of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
Yuying LiuDivision of Gastroenterology, Departments of Pediatrics, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, United States.
The University of Texas Health Science Center at Houston · USLouisiana State University · USLouisiana State University Health Sciences Center New Orleans · USThe University of Texas MD Anderson Cancer Center · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Mechanisms of L. reuteri in regulating intestinal inflammationR01AT007083 · NCCIH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YUYING, RHOADS, JON MARC · 2014 to 2018
$1.7M
NCCIH NIH HHS R01 AT007083NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

The gut microbiome plays an important role in immune function and has been implicated in multiple sclerosis (MS). However, how and if the modulation of microbiota can prevent or treat MS remain largely unknown. In this study, we showed that probiotic

Indexed as

Gastrointestinal MicrobiomeLimosilactobacillus reuteriAnimalsEncephalomyelitis, Autoimmune, ExperimentalFemaleMiceMice, Inbred C57BLProbioticsexperimental autoimmune encephalomyelitisgut microbiotaIFN-γ/IL-17Lactobacillus reuteriTH1/TH17 cells

Identifiers

PMID30899262
PMCPMC6416370
OpenAlexW2912152411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.