Evidence map›Paper›PMID 30899260›Full record

ArticleFrontiers in immunology2019

Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet.

Belal Chami, Farjaneh Hossain, Thomas W Hambly, Xiaoping Cai, Roshanak Aran, Genevieve Fong, Abigail Vellajo, Nathan J J Martin, XiaoSuo Wang, Joanne M Dennis and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Serum amyloid A in HFpEF and cardiometabolic diseases.Basic research in cardiology · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Role of serum amyloid A in atherosclerosis.Current opinion in lipidology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Belal ChamiDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Farjaneh HossainDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Thomas W HamblyDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Xiaoping CaiDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Roshanak AranDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Genevieve FongDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Abigail VellajoDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Nathan J J MartinDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
XiaoSuo WangDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Joanne M DennisDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Arpeeta SharmaDepartment of Medicine, Monash University, Melbourne, VIC, Australia.
Waled A ShihataCardiovascular Disease Program, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Jaye P F Chin-DustingCardiovascular Disease Program, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, Australia.
Judy B de HaanBaker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Alexandra SharlandTransplantation Immunobiology Group, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Carolyn L GeczySchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Ben FreedmanANZAC Research and Heart Research Institutes, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Paul K WittingDiscipline of Pathology, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
University of Sydney · AUBaker Heart and Diabetes Institute · AUMonash University · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE

Indexed as

AnimalsAortaApolipoproteins EBiomarkersBlood VesselsCytokinesDisease Models, AnimalDisease SusceptibilityEndothelial CellsImmunohistochemistryInflammation MediatorsKidney DiseasesKidney Function TestsLipidsMacrophagesMaleApolipoproteins EBiomarkersCytokinesInflammation MediatorsLipidsPeroxidaseSerum Amyloid A Proteinacute-phase proteinendothelial functioninflammationnitric oxiderenal dysfunction

Identifiers

PMID30899260
PMCPMC6416175
OpenAlexW2920809209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.