ArticleFrontiers in neurology2019
Longitudinal Recordings Reveal Transient Increase of Alpha/Low-Beta Power in the Subthalamic Nucleus Associated With the Onset of Parkinsonian Rest Tremor.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Linking cortical morphology and neurophysiological dynamics in Parkinson's disease.Scientific reports · 2026Article
- Levodopa exacerbated tremor in Parkinson's disease.Frontiers in neurology · 2026Article
- A Distributed Oscillatory Network Model of Parkinsonian Tremor: Integrating Basal Ganglia and Cerebello-Thalamic Circuits.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Review
- Linking Cortical Morphology and Neurophysiological Dynamics in Parkinson's Disease.Research square · 2025Article
- Multivariate Associations Between Neurophysiological Activity and Sensory Motor Cortical Morphometry in Parkinson's Disease.bioRxiv : the preprint server for biology · 2025Article
- Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics.Brain sciences · 2025Review
- Parkinson's disease tremor explained by reflex loop changes.Scientific reports · 2025Article
- The Place of Local Field Potentials in Deep Brain Stimulation Programming for Parkinson's Disease: A Review.Brain sciences · 2025Review
- Clinico-physiological correlates of Parkinson's disease from multi-resolution basal ganglia recordings.NPJ Parkinson's disease · 2024Article
- Gait-related beta-gamma phase amplitude coupling in the subthalamic nucleus of parkinsonian patients.Scientific reports · 2024Article
- Paradoxical Modulation of STN β-Band Activity with Medication Compared to Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Reconstructing Re-emergent Tremor.Movement disorders clinical practice · 2023Article
- Integrative Brain States Facilitate the Expression of Parkinson's Tremor.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Closed-Loop Adaptive Deep Brain Stimulation in Parkinson's Disease: Procedures to Achieve It and Future Perspectives.Journal of Parkinson's disease · 2023Review
- Pharmacological Treatment of Tremor in Parkinson's Disease Revisited.Journal of Parkinson's disease · 2023Review
- Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson's Disease.Brain sciences · 2022Article
- Subthalamic-Cortical Network Reorganization during Parkinson's Tremor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Debugging Adaptive Deep Brain Stimulation for Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Review
- Tremor in Parkinson's Disease May Arise from Interactions of Central Rhythms with Spinal Reflex Loop Oscillations.Journal of Parkinson's disease · 2020Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional magnetic resonance imaging studies suggest that different subcortico-cortical circuits control different aspects of Parkinsonian rest tremor. The basal ganglia were proposed to drive tremor onset, and the cerebellum was suggested to be responsible for tremor maintenance ("dimmer-switch" hypothesis). Although several electrophysiological correlates of tremor have been described, it is currently unclear whether any of these is specific to tremor onset or maintenance. In this study, we present data from a single patient measured repeatedly within 2 years after implantation of a deep brain stimulation (DBS) system capable of recording brain activity from the target. Local field potentials (LFPs) from the subthalamic nucleus and the scalp electroencephalogram were recorded 1 week, 3 months, 6 months, 1 year, and 2 years after surgery. Importantly, the patient suffered from severe rest tremor of the lower limbs, which could be interrupted voluntarily by repositioning the feet. This provided the unique opportunity to record many tremor onsets in succession. We found that tremor onset and tremor maintenance were characterized by distinct modulations of subthalamic oscillations. Alpha/low-beta power increased transiently immediately after tremor onset. In contrast, beta power was continuously suppressed during tremor maintenance. Tremor maintenance was additionally associated with subthalamic and cortical power increases around individual tremor frequency. To our knowledge, this is the first evidence of distinct subthalamic LFP modulations in tremor onset and tremor maintenance. Our observations suggest the existence of an acceleration signal for Parkinsonian rest tremor in the basal ganglia, in line with the "dimmer-switch" hypothesis.
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