Evidence map›Paper›PMID 30899224›Full record

ArticleFrontiers in physiology2019

UNICORN Babies: Understanding Circulating and Cerebral Creatine Levels of the Preterm Infant. An Observational Study Protocol.

Mary J Berry, Melissa Schlegel, Greg M Kowalski, Clinton R Bruce, Damien L Callahan, Miranda L Davies-Tuck, Hayley Dickinson, Angus Goodson, Angie Slocombe, Rod J Snow and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause.Journal of the International Society of Sports Nutrition · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Mary J BerryDepartment of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.
Melissa SchlegelDepartment of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.
Greg M KowalskiSchool of Exercise Sciences, Institute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.
Clinton R BruceSchool of Exercise Sciences, Institute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.
Damien L CallahanCentre for Cellular and Molecular Biology, School of Life and Environmental Science, Deakin University, Melbourne, VIC, Australia.
Miranda L Davies-TuckThe Ritchie Centre, Hudson Institute of Medical Research, and Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
Hayley DickinsonThe Ritchie Centre, Hudson Institute of Medical Research, and Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
Angus GoodsonCapital and Coast District Health Board, Wellington, New Zealand.
Angie SlocombeCapital and Coast District Health Board, Wellington, New Zealand.
Rod J SnowSchool of Exercise Sciences, Institute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.
David W WalkerSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
Stacey J ElleryThe Ritchie Centre, Hudson Institute of Medical Research, and Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
Capital and Coast District Health Board · NZDeakin University · AUMonash University · AUHudson Institute of Medical Research · AURMIT University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Creatine is an essential metabolite for brain function, with a fundamental role in cellular (ATP) energy homeostasis. It is hypothesized that preterm infants will become creatine deplete in the early postnatal period, due to premature delivery from a maternal source of creatine and a limited supply of creatine in newborn nutrition. This potential alteration to brain metabolism may contribute to, or compound, poor neurological outcomes in this high-risk population. Understanding Creatine for Neurological Health in Babies (UNICORN) is an observational study of circulating and cerebral creatine levels in preterm infants. We will recruit preterm infants at gestational ages 23

Indexed as

brain metabolismcellular energyneurodevelopmentnutritionpremature

Identifiers

PMID30899224
PMCPMC6417365
OpenAlexW2922474611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.