ArticleScientific reports2019
Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Integrated Histological and Transcriptomic Analyses Reveal Distinct Structural and Molecular Features of the Calipash and Muscle in the Chinese Soft-Shelled Turtle (Animals : an open access journal from MDPI · 2026Article
- A millimetre-scale capacitive biosensing and biophysical stimulation system for emerging bioelectronic bone implants.Journal of the Royal Society, Interface · 2024Article
- Self-adaptive rotational electromagnetic energy generation as an alternative to triboelectric and piezoelectric transductions.Communications engineering · 2024Article
- Gathering Evidence to Leverage Musculoskeletal Magnetic Stimulation Towards Clinical Applicability.Small science · 2024Article
- The application of impantable sensors in the musculoskeletal system: a review.Frontiers in bioengineering and biotechnology · 2024Review
- Bioelectronic multifunctional bone implants: recent trends.Bioelectronic medicine · 2022Review
- Multiscale Sensing of Bone-Implant Loosening for Multifunctional Smart Bone Implants: Using Capacitive Technologies for Precision Controllability.Sensors (Basel, Switzerland) · 2022Article
- Multifunctional Smart Bone Implants: Fiction or Future?-A New Perspective.Frontiers in bioengineering and biotechnology · 2022Article
- Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implants.NPJ Regenerative medicine · 2021Article
- Hybrid Triboelectric-Electromagnetic Nanogenerators for Mechanical Energy Harvesting: A Review.Nano-micro letters · 2021Review
- Multimodal Sensing Capabilities for the Detection of Shunt Failure.Sensors (Basel, Switzerland) · 2021Article
- Towards an effective sensing technology to monitor micro-scale interface loosening of bioelectronic implants.Scientific reports · 2021Article
- Improving the Effect of Transcranial Alternating Current Stimulation (tACS): A Systematic Review.Frontiers in human neuroscience · 2021Review
- Article
- Theoretical and Experimental Investigations of a Pseudo-Magnetic Levitation System for Energy Harvesting.Sensors (Basel, Switzerland) · 2020Article
- Natural and Eco-Friendly Materials for Triboelectric Energy Harvesting.Nano-micro letters · 2020Review
- Altering the Course of Technologies to Monitor Loosening States of Endoprosthetic Implants.Sensors (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cosurface electrode architectures are able to deliver personalized electric stimuli to target tissues. As such, this technology holds potential for a variety of innovative biomedical devices. However, to date, no detailed analyses have been conducted to evaluate the impact of stimulator architecture and geometry on stimuli features. This work characterizes, for the first time, the electric stimuli delivered to bone cellular tissues during in vitro experiments, when using three capacitive architectures: stripped, interdigitated and circular patterns. Computational models are presented that predict the influence of cell confluence, cosurface architecture, electrodes geometry, gap size between electrodes and power excitation on the stimuli delivered to cellular layers. The results demonstrate that these stimulators are able to deliver osteoconductive stimuli. Significant differences in stimuli distributions were observed for different stimulator designs and different external excitations. The thickness specification was found to be of utmost importance. In vitro experiments using an osteoblastic cell line highlight that cosurface stimulation at a low frequency can enhance osteoconductive responses, with some electrode-specific differences being found. A major feature of this type of work is that it enables future detailed analyses of stimuli distribution throughout more complex biological structures, such as tissues and organs, towards sophisticated biodevice personalization.
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Registered trials
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