Evidence map›Paper›PMID 30899044›Full record

ArticleScientific reports2019

The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock

Austin T H Duong, Cristine J Reitz, Emma L Louth, Samantha D Creighton, Mina Rasouli, Ashley Zwaiman, Jeffrey T Kroetsch, Steffen-Sebastian Bolz, Boyer D Winters, Craig D C Bailey and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Circadian influence on the microbiome improves heart failure outcomes.Journal of molecular and cellular cardiology · 2020
    Article
  13. Old and New Roles and Evolving Complexities of Cardiovascular Clocks.The Yale journal of biology and medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Austin T H DuongCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Cristine J ReitzCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Emma L LouthCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Samantha D CreightonDepartment of Psychology, University of Guelph, Guelph, Ontario, Canada.
Mina RasouliCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Ashley ZwaimanCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Jeffrey T KroetschDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Steffen-Sebastian BolzDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Boyer D WintersDepartment of Psychology, University of Guelph, Guelph, Ontario, Canada.
Craig D C BaileyCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada. baileyc@uoguelph.ca.
Tami A MartinoCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada. tmartino@uoguelph.ca.ORCID 0000-0003-1913-8416

Funding

CIHR
6 · The paper itself

Abstract

In this study we investigated the role of the circadian mechanism on cognition-relevant brain regions and neurobiological impairments associated with heart failure (HF), using murine models. We found that the circadian mechanism is an important regulator of healthy cognitive system neurobiology. Normal Clock

Indexed as

AcclimatizationAnimalsCircadian RhythmCLOCK ProteinsDendritesDisease Models, AnimalHeart FailureHippocampusHumansMemoryMiceNeuronsPrefrontal CortexSignal TransductionClock protein, mouseCLOCK Proteins

Identifiers

PMID30899044
PMCPMC6428811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.