Evidence map›Paper›PMID 30898864›Full record

ReviewBlood2019

Inflammatory consequences of inherited disorders affecting neutrophil function.

Mary C Dinauer

Open access · bronzeAbstract readReview
In one paragraph

Review in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 71 citations in OpenAlex.

  1. Many Cells Make Light Work: Self-Generated Gradients OrganizeCold Spring Harbor perspectives in biology · 2026
    Review
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  6. Case Report: NovelFrontiers in immunology · 2026
    Article
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  13. A LTBiScience · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mary C DinauerDepartment of Pediatrics and Department of Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO.
Washington University in St. Louis · US

Funding

STRUCTURE/FUNCTION ANALYSIS OF PHAGOCYTE PROTEINSR01HL045635 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI DINAUER, MARY C · 1991 to 2009
$3.0M
Leukocyte NADPH Oxidase Variants in LupusR01AR072212 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JACOB, CHAIM O. · 2017 to 2022
$2.8M
SELECTIVE DELETION OF NEUTROPHIL NADPH OXIDASE AND INNATE RESPONSES TO ASPERGILLUS FUMIGATUSR01HL140837 · NHLBI · WASHINGTON UNIVERSITY · PI DINAUER, MARY C · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL045635NHLBI NIH HHS R01 HL140837NIAMS NIH HHS R01 AR072212
6 · The paper itself

Abstract

Primary immunodeficiencies affecting the function of neutrophils and other phagocytic leukocytes are notable for an increased susceptibility to bacterial and fungal infections as a result of impaired leukocyte recruitment, ingestion, and/or killing of microbes. The underlying molecular defects can also impact other innate immune responses to infectious and inflammatory stimuli, leading to inflammatory and autoimmune complications that are not always directly related to infection. This review will provide an update on congenital disorders affecting neutrophil function in which a combination of host defense and inflammatory complications are prominent, including nicotinamide dinucleotide phosphate oxidase defects in chronic granulomatous disease and β2 integrin defects in leukocyte adhesion deficiency.

Indexed as

AnimalsAutoimmune DiseasesGenetic VariationGranulomatous Disease, ChronicHumansImmunity, InnateInflammationNADPH OxidasesNeutrophilsNADPH Oxidases

Identifiers

PMID30898864
PMCPMC6524563
OpenAlexW2923309584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.