Evidence map›Paper›PMID 30898807›Full record

ArticleBMJ open2019

Obesity and recovery from acute kidney injury (Ob AKI): a prospective cohort feasibility study.

Helen L MacLaughlin, Rochelle M Blacklock, Kelly Wright, Gerda Pot, Satish Jayawardene, Christopher W McIntyre, Iain C Macdougall, Nicholas M Selby

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Prediction Models for AKI in ICU: A Comparative Study.International journal of general medicine · 2021
    Article
  7. Obese trauma patients have increased need for dialysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020
    Article
  8. Individualized acute kidney injury after care.Current opinion in critical care · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Helen L MacLaughlinDepartment of Nutrition and Dietetics, King's College Hospital NHS Foundation Trust, London, UK.ORCID 0000-0001-9617-546X
Rochelle M BlacklockDepartment of Nutrition and Dietetics, King's College Hospital NHS Foundation Trust, London, UK.
Kelly WrightDepartment of Renal Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Gerda PotDepartment of Nutritional Sciences, King's College London, London, UK.
Satish JayawardeneDepartment of Renal Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Christopher W McIntyreDivision of Nephrology, University of Western Ontario, Ontario, UK.
Iain C MacdougallDepartment of Renal Medicine, King's College Hospital NHS Foundation Trust, London, UK.
Nicholas M SelbyCentre for Kidney Research and Innovation, University of Nottingham Faculty of Medicine and Health Sciences, Derby, UK.ORCID 0000-0003-0351-8326
King's College Hospital NHS Foundation Trust · GBKing's College London · GBUniversity of Nottingham · GB

Funding

Department of Health CAT CL-2014-05-005
6 · The paper itself

Abstract

objectivesTo test the methodology of recruitment, retention and data completeness in a prospective cohort recruited after a hospitalised episode of acute kidney injury (AKI), to inform a future prospective cohort study examining the effect of obesity on AKI outcomes.

designFeasibility study.

settingSingle centre, multi-site UK tertiary hospital.

participants101 participants (67M; 34F) with a median age of 64 (IQR 53-73) years, with and without obesity, recruited within 3 months of a hospitalised episode of AKI. OUTCOME MEASURES: Feasibility outcomes were recruitment (>15% meeting inclusion criteria recruited), participant retention at 6 and 12 months (≥80%) and completeness of data collection. Exploratory measures included recovery from AKI (regaining >75% of pre-AKI estimated glomerular filtration rate [eGFR]) at 6 months, development or progression of chronic kidney disease (CKD) (kidney function decrease of ≥25% +  rise in CKD category) at 12 months, and associations with poorer kidney outcomes.

results41% of eligible patients consented to take part, exceeding the target recruitment uptake rate of 15%. Retention was 86% at 6 months and 78% at 12 months; 10 patients died and three commenced dialysis during the study. Data were 90%-100% complete. Median BMI was 27.9 kg/m

conclusionsFeasibility to conduct a long-term observational study addressing AKI outcomes associated with obesity was demonstrated. A fully powered prospective cohort study to examine the relationships between obesity and outcomes of AKI is warranted.

Indexed as

Acute Kidney InjuryAgedBiomarkersCystatin CDisease ProgressionFeasibility StudiesFemaleGlomerular Filtration RateHumansInterleukin-6LondonMaleMiddle AgedObesityObservational Studies as TopicProspective StudiesBiomarkersCystatin CInterleukin-6acute renal failurechronic renal failureobesity

Identifiers

PMID30898807
PMCPMC6528015
OpenAlexW2923115152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.