Evidence map›Paper›PMID 30898791›Full record

ArticleBMJ open2019

Retrospective study of irrational prescribing in French paediatric hospital: prevalence of inappropriate prescription detected by Pediatrics: Omission of Prescription and Inappropriate prescription (POPI) in the emergency unit and in the ambulatory setting.

Aurore Berthe-Aucejo, Phuong Khanh Hoang Nguyen, François Angoulvant, Xavier Bellettre, Patrick Albaret, Thomas Weil, Rym Boulkedid, Olivier Bourdon, Sonia Prot-Labarthe

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Aurore Berthe-AucejoDepartment of Pharmacy, AP-HP, Robert-Debré Hospital, Paris, France.
Phuong Khanh Hoang NguyenDepartment of Pharmacy, AP-HP, Robert-Debré Hospital, Paris, France.
François AngoulvantUMR-S1123, ECEVE; Inserm U1123, INSERM, Paris, Île-de-France, France.
Xavier BellettreEmergency unit, AP-HP, Robert-Debré Hospital, Paris, Île-de-France, France.
Patrick AlbaretPharmacy, Albaret Pharmacy, Cesson, France.
Thomas WeilDepartment of Pharmacy, AP-HP, Robert-Debré Hospital, Paris, France.
Rym BoulkedidUMR-S1123, ECEVE; Inserm U1123, INSERM, Paris, Île-de-France, France.
Olivier BourdonDepartment of Pharmacy, AP-HP, Robert-Debré Hospital, Paris, France.
Sonia Prot-LabartheDepartment of Pharmacy, AP-HP, Robert-Debré Hospital, Paris, France.
Assistance Publique – Hôpitaux de Paris · FRHôpital Robert-Debré · FRInserm · FRDélégation Paris 5 · FRHôpital Necker-Enfants Malades · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivePediatrics: Omission of Prescription and Inappropriate prescription (POPI) is the first detection tool for potentially inappropriate medicines (PIMs) and potentially prescribing omissions (PPOs) in paediatrics. The aim of this study was to evaluate the prevalence of PIM and PPO detected by POPI regarding prescriptions in hospital and for outpatients. The second objective is to determine the risk factors related to PIM and PPO.

designA retrospective, descriptive study was conducted in the emergency department (ED) and community pharmacy (CP) during 6 months. POPI was used to identify PIM and PPO.

settingRobert-Debré Hospital (France) and Albaret community pharmacy (Seine and Marne).

participantsPatients who were under 18 years old and who had one or more drugs prescribed were included. Exclusion criteria consisted of inaccessible medical records for patients consulted in ED and prescription without drugs for outpatients. PRIMARY AND SECONDARY OUTCOME MEASURES: PIM and PPO rate and risk factors.

resultsAt the ED, 18 562 prescriptions of 15 973 patients and 4780 prescriptions of 2225 patients at the CP were analysed. The PIM rate and PPO rate were, respectively, 2.9% and 2.3% at the ED and 12.3% and 6.1% at the CP. Respiratory and digestive diseases had the highest rate of PIM.

conclusionThis is the first study to assess the prevalence of PIM and PPO detected by POPI in a paediatric population. This study assessed PIMs or PPOs within a hospital and a community pharmacy. POPI could be used to improve drug use and patient care and to limit hospitalisation and adverse drug reaction. A prospective multicentric study should be conducted to evaluate the impact and benefit of implementing POPI in clinical practice.

Indexed as

Emergency Service, HospitalInappropriate PrescribingMedical ErrorsPediatricsPharmaciesChildChild, PreschoolFemaleFranceHumansMaleMedication Therapy ManagementPatient SafetyPotentially Inappropriate Medication ListPractice Patterns, Physicians'Prevalencedetectioninappropriate prescriptionomissiontool

Identifiers

PMID30898791
PMCPMC6475152
OpenAlexW2923358138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.