ArticleNeurobiology of learning and memory2019
Pathway specific activation of ventral hippocampal cells projecting to the prelimbic cortex diminishes fear renewal.
Article in Neurobiology of learning and memory, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study.Psychopharmacology · 2026Trial
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Molecular architects of memory: BDNF/TrkB signaling and trafficking in neuronal plasticity and memory.Molecular psychiatry · 2026Review
- Review
- Ventral Hippocampus Modulates Prefrontal Control of Background Contextual Fear After Cued Extinction.The European journal of neuroscience · 2025Article
- Chemogenetic inhibition of the ventral hippocampus but not its direct projection to the prelimbic cortex attenuates context-specific operant responding.Frontiers in behavioral neuroscience · 2024Article
- Neural circuits for the adaptive regulation of fear and extinction memory.Frontiers in behavioral neuroscience · 2024Review
- Rewarded Maze Training Increases Approach Behavior in Rats Through Neurogenesis-Dependent Growth of Ventral Hippocampus-Prelimbic Circuits.Biological psychiatry global open science · 2023Article
- Memory retrieval, reconsolidation, and extinction: Exploring the boundary conditions of post-conditioning cue exposure.Frontiers in synaptic neuroscience · 2023Review
- Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions.Frontiers in behavioral neuroscience · 2022Article
- Dissecting the Prefrontal Network With Pathway-Selective Manipulation in the Macaque Brain-A Review.Frontiers in neuroscience · 2022Review
- Hippocampal Inputs in the Prelimbic Cortex Curb Fear after Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain.Communications biology · 2021Article
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- BEHAVIORAL AND NEUROBIOLOGICAL MECHANISMS OF PAVLOVIAN AND INSTRUMENTAL EXTINCTION LEARNING.Physiological reviews · 2021Review
- Genetic Depletion of BDNF Impairs Extinction Learning of a Spatial Appetitive Task in the Presence or Absence of the Acquisition Context.Frontiers in behavioral neuroscience · 2021Article
- Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring.Addiction biology · 2021Article
- Molecularly Defined Hippocampal Inputs Regulate Population Dynamics in the Prelimbic Cortex to Suppress Context Fear Memory Retrieval.Biological psychiatry · 2020Article
- Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders.Molecular psychiatry · 2020Review
- Anabolic-androgenic steroid abuse and cognitive impairment: Testosterone IMPAIRS biconditional task performance in male rats.Behavioural brain research · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The ability to learn that a stimulus no longer signals danger is known as extinction. A major characteristic of extinction is that it is context-dependent, which means that fear reduction only occurs in the same context as extinction training. In other contexts, there is re-emergence of fear, known as contextual renewal. The ability to properly extinguish fear memories and generalize safety associations to multiple contexts provides therapeutic potential, but little is known about the specific neural pathways that mediate fear renewal and extinction generalization. The ventral hippocampus (VH) is thought to provide a contextual gating mechanism that determines whether fear or safety is expressed in particular contexts through its projections to areas of the fear circuit, including the infralimbic (IL) and prelimbic (PL) cortices. Moreover, VH principal cells fire in large, overlapping regions of the environment, a characteristic that is ideal to support generalization; yet it is unclear how different projection cells mediate this process. Using a pathway-specific (intersectional) chemogenetic approach, we demonstrate that selective activation of VH cells projecting to PL attenuates fear renewal without affecting fear expression. These results have implications for anxiety disorders since they uncover a neural pathway associated with extinction generalization.
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