ReviewNeurobiology of disease2019
Multiscale recordings reveal the dynamic spatial structure of human seizures.
Review in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.EBioMedicine · 2025Trial
- Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A primary mechanism for efficacy of the ketogenic diet may be energy repletion at the tripartite synapse.Journal of neural engineering · 2025Article
- Mesoscale insights in Epileptic Networks: A Multimodal Intracranial Dataset.Scientific data · 2025Article
- Interictal discharges spread along local recurrent networks between tubers and surrounding cortex.The Journal of physiology · 2025Article
- A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures.Neuropharmacology · 2025Article
- Highly local activation of inhibition at the seizure wavefront in vivo.Cell reports · 2024Article
- Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.Brain : a journal of neurology · 2023Article
- Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring.Cell reports · 2023Article
- Article
- Putative roles for homeostatic plasticity in epileptogenesis.Epilepsia · 2023Review
- Local neuronal excitation and global inhibition during epileptic fast ripples in humans.Brain : a journal of neurology · 2023Article
- Distinct signatures of loss of consciousness in focal impaired awareness versus tonic-clonic seizures.Brain : a journal of neurology · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Early EEG hyperexcitability is associated with decreased survival in newly diagnosed IDH-wildtype glioma.Journal of neuro-oncology · 2022Observational
- Repeated hippocampal seizures lead to brain-wide reorganization of circuits and seizure propagation pathways.Neuron · 2022Article
- Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.Brain communications · 2022Article
- Ictal wavefront propagation in slices and simulations with conductance-based refractory density model.PLoS computational biology · 2022Article
- Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale.Communications biology · 2021Article
- Neuronal Firing and Waveform Alterations through Ictal Recruitment in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
The cellular activity underlying human focal seizures, and its relationship to key signatures in the EEG recordings used for therapeutic purposes, has not been well characterized despite many years of investigation both in laboratory and clinical settings. The increasing use of microelectrodes in epilepsy surgery patients has made it possible to apply principles derived from laboratory research to the problem of mapping the spatiotemporal structure of human focal seizures, and characterizing the corresponding EEG signatures. In this review, we describe results from human microelectrode studies, discuss some data interpretation pitfalls, and explain the current understanding of the key mechanisms of ictogenesis and seizure spread.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.