ArticleBiological psychiatry2019
Age-Normative Pathways of Striatal Connectivity Related to Clinical Symptoms in the General Population.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 32 citations in OpenAlex.
- Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin.Molecular autism · 2021Trial
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Differential trajectories of corticostriatal structural connectivity in individuals at clinical high risk for psychosis according to functional outcome.Translational psychiatry · 2025Article
- Longitudinal changes in striatocortical connectivity in first-episode psychosis associated with the emergence of treatment resistance.Schizophrenia (Heidelberg, Germany) · 2025Article
- Alterations of spontaneous brain activity in type 2 diabetes mellitus without mild cognitive impairment: a resting-state functional magnetic resonance study.Frontiers in human neuroscience · 2023Article
- Is genetic risk of ADHD mediated via dopaminergic mechanism? A study of functional connectivity in ADHD and pharmacologically challenged healthy volunteers with a genetic risk profile.Translational psychiatry · 2022Article
- Frontal corticostriatal functional connectivity reveals task positive and negative network dysregulation in relation to ADHD, sex, and inhibitory control.Developmental cognitive neuroscience · 2022Article
- Abnormal functional connectivity of the frontostriatal circuits in type 2 diabetes mellitus.Frontiers in aging neuroscience · 2022Article
- Effects of comorbid disorders on reward processing and connectivity in adults with ADHD.Translational psychiatry · 2021Article
- Associations between peripheral inflammation and resting state functional connectivity in adolescents.Brain, behavior, and immunity · 2021Article
- Beneath the surface: hyper-connectivity between caudate and salience regions in ADHD fMRI at rest.European child & adolescent psychiatry · 2021Article
- Development of lateral pulvinar resting state functional connectivity and its role in attention.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Adolescent substance use and functional connectivity between the ventral striatum and hippocampus.Behavioural brain research · 2020Article
- Increased Reward-Related Activation in the Ventral Striatum During Stress Exposure Associated With Positive Affect in the Daily Life of Young Adults With a Family History of Depression. Preliminary Findings.Frontiers in psychiatry · 2020Article
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9 authors at 4 institutions in 1 country.
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Abstract
backgroundAltered striatal development contributes to core deficits in motor and inhibitory control, impulsivity, and inattention associated with attention-deficit/hyperactivity disorder and may likewise play a role in deficient reward processing and emotion regulation in psychosis and depression. The maturation of striatal connectivity has not been well characterized, particularly as it relates to clinical symptomatology.
methodsResting-state functional connectivity with striatal subdivisions was examined for 926 participants (8-22 years of age, 44% male) from the general population who had participated in two large cross-sectional studies. Developing circuits were identified and growth charting of age-related connections was performed to obtain individual scores reflecting relative neurodevelopmental attainment. Associations of clinical symptom scales (attention-deficit/hyperactivity disorder, psychosis, depression, and general psychopathology) with the resulting striatal connectivity age-deviation scores were then tested using elastic net regression.
resultsLinear and nonlinear developmental patterns occurred across 231 striatal age-related connections. Both unique and overlapping striatal age-related connections were associated with the four symptom domains. Attention-deficit/hyperactivity disorder severity was related to age-advanced connectivity across several insula subregions, but to age-delayed connectivity with the nearby inferior frontal gyrus. Psychosis was associated with advanced connectivity with the medial prefrontal cortex and superior temporal gyrus, while aberrant limbic connectivity predicted depression. The dorsal posterior insula, a region involved in pain processing, emerged as a strong contributor to general psychopathology as well as to each individual symptom domain.
conclusionsDevelopmental striatal pathophysiology in the general population is consistent with dysfunctional circuitry commonly found in clinical populations. Atypical age-normative connectivity may thereby reflect aberrant neurodevelopmental processes that contribute to clinical risk.
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