ArticleTrends in cancer2019
Mouse Models Shed Light on the SLIT/ROBO Pathway in Pancreatic Development and Cancer.
Article in Trends in cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- SLIT/ROBO Pathway and Prostate Cancer: Gene and Protein Expression and Their Prognostic Values.International journal of molecular sciences · 2025Article
- The molecular logic of early metastasis in pancreatic cancer: crosstalk between tumor and microenvironment.Frontiers in cell and developmental biology · 2025Review
- Targeting Perineural Invasion in Pancreatic Cancer.Cancers · 2024Review
- ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness.Cell death & disease · 2022Article
- Single-nucleus transcriptomic landscape of primate hippocampal aging.Protein & cell · 2021Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SLIT/ROBO pathway is classically known for its role in axon guidance, and is frequently lost in pancreatic cancer, but the biology behind this is poorly understood. Two recent articles (Nat. Commun. 2018;9:5082; Nat. Commun. 2018;9:5083) using mouse models show that SLIT/ROBO signaling is crucial to determine pancreatic cell identity during development and suppresses the stromal activation in disease, through divergent mechanisms. SLIT/ROBO proteins thus link development and cancer, but appear to have distinct functions in health and disease.
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Registered trials
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