Evidence map›Paper›PMID 30898022›Full record

ArticleVirulence2019

Differential immune responses of C57BL/6 mice to infection by Salmonella enterica serovar Typhimurium strain SL1344, CVCC541 and CMCC50115.

Shao Wei, Jianwei Huang, Zhexi Liu, Mengyao Wang, Bingkun Zhang, Zhengxing Lian, Yuming Guo, Hongbing Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. A TCRVβ6Journal of cellular and molecular medicine · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Virulence Comparison ofMicroorganisms · 2021
    Article
  11. Article
  12. Article
  13. Microorganisms · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shao Weia State Key Laboratory of Animal Nutrition, College of Animal Science and Technology , China Agricultural University , Beijing , China.
Jianwei Huangb Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology , China Agricultural University , Beijing , China.
Zhexi Liub Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology , China Agricultural University , Beijing , China.
Mengyao Wangb Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology , China Agricultural University , Beijing , China.
Bingkun Zhanga State Key Laboratory of Animal Nutrition, College of Animal Science and Technology , China Agricultural University , Beijing , China.
Zhengxing Lianb Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology , China Agricultural University , Beijing , China.
Yuming Guoa State Key Laboratory of Animal Nutrition, College of Animal Science and Technology , China Agricultural University , Beijing , China.
Hongbing Hanb Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology , China Agricultural University , Beijing , China.
China Agricultural University · CNMinistry of Agriculture and Rural Affairs · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With a broad range of hosts, Salmonella enterica serovar Typhimurium (S. Typhimurium) is the major cause of gastroenteritis in human beings and systemic disease in susceptible mice strains. However, different S. Typhimurium strains differ in regard to virulence and host adaptation. Here, C57BL/6 mice were infected, respectively, with different S. Typhimurium strains SL1344 (calf), CVCC541 (chicken) and CMCC50115 (mutton) to determine their virulence and host immune responses. It was found that mice were less susceptible to infection by S. Typhimurium CVCC541 and CMCC50115 strains, with lower lethality and decreased bacterial burden in liver and spleen. Besides, S. Typhimurium strains CVCC541 and CMCC50115 enhanced host innate immune responses by increased frequencies of macrophages and neutrophils 3 days after infection. But SL1344 strain evaded immune response by inducing apoptosis of macrophages. Moreover, CVCC541 could elicit adaptive immune responses of host 11 days after infection upon examination of the proliferation and activation of CD4

Indexed as

AnimalsAntigen-Presenting CellsFemaleGenetic VariationImmunity, InnateMiceMice, Inbred C57BLMutationSalmonella entericaSalmonella Infections, AnimalSpecies SpecificityT-LymphocytesVirulenceimmune responsemiceserovar Typhimuriumvirulence

Identifiers

PMID30898022
PMCPMC6527021
OpenAlexW2924333659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.